Mrs. Frankenstein/Gym Teacher/Weird Girl
Catherine O'Hara
Victor Frankenstein (voice)
Charlie Tahan
Mr. Frankenstein / Mr. Burgemeister / Nassor (voice)
Martin Short
Elsa Van Helsing (voice)
Winona Ryder
Mr. Rzykruski (voice)
Martin Landau
Mr. Rzykruski
Martin Landau
Edgar "E" Gore (voice)
Atticus Shaffer
Bob
Robert Capron
Toshiaki (voice)
James Hiroyuki Liao
Bob's Mom
Conchata Ferrell
New Holland Townsfolk (voice)
Tom Kenny
Sparky Frankenstein (voice)
Frank Welker
Persephone van Helsing / Shelly / Were-Rat / Colossus
Dee Bradley Baker
Giant Sea Monkeys (voice)
Jeff Bennett
Movie Dracula (archive footage)
Christopher Lee