Mr. Popper

Jim Carrey

Amanda

Carla Gugino

Mrs. Van Gundy

Angela Lansbury

Pippi

Ophelia Lovibond

Janie

Madeline Carroll

Nat Jones

Clark Gregg

Billy Popper

Maxwell Perry Cotton

Mr. Gremmins

Jeffrey Tambor

Kent

David Krumholtz

Franklin

Philip Baker Hall

Rick

James Tupper

Reader

Dominic Chianese

Yates

William C. Mitchell

Young Tommy Popper

Henry Keleman

Tommy's Mom

Kelli Barrett

Young Tommy Popper #2

Dylan Clark Marshall

Daryl

Desmin Borges

Young Tom Popper, Sr. (voice)

Brian T. Delaney

Gremmins's Secretary

Elaine Kussack

Town Car Driver

Harlin C. Kearsley

Reginald

Lee Moore

Tito

Dominic Colón

Freddy

Jeff Lima

Klaus

Frank Ciornei

Klaus

Frank Cornei

Arnold

J.R. Horne

Antarctic Friend

Matthew Wolf

Animal Control Guy

Andrew Stewart-Jones

Fish & Game Officer

James Chen

Marine & Waterfowl Officer

Rafael Osorio

Sanitation Officer

Curtis Shumaker

Random Man on Street

Joseph D'Onofrio

Nanny

Olga Merediz

Tavern Hostess

Betsy Aidem

Fishmonger

Angel L. Cabán

Young Developer

Chris Beetem

Old Tom Popper Sr.

Charles L. Campbell

Zoo Security Guard

Daniel Stewart Sherman

Cop #1

Mike Massimino

Cop #2 (Quint)

Charlie Semine

Pulse Lounge Beautiful Girl (uncredited)

Cynthia Kirchner

Jared Stern

Florence Atwater