Bruce

Masi Oka

Lloyd

Nate Torrence

Nina

Jayma Mays

Isabella

Marika Dominczyk

Bob

Mitch Rouse

Neil

J.P. Manoux

Underchief/CIA Chief

Larry Miller

Howard

Bryan Callen

Judy

Kelly Karbacz

Matre D'

Terry Rhoads

Hymie

Patrick Warburton

Lab

Brian Gattas

El Presidente

Rubén Garfias

Steve Carell

Upside Down Guy

Sunkrish Bala

Agent 99 (Uncredited)

Anne Hathaway

Waitress

Erica Zodtner

Dwayne Johnson

Scientist

Winston J. Rocha

Alan Arkin

Young Isabella

Brianna Rain King

C.I.A. Guy

Matt Kaminsky

Terence Stamp

Agent 91

Terry Crews

Senior Guard

Al Coronel

Woman in Dress

Luisa Moraes

David Koechner

Agent 34

Amanda Tosch

Bill Murray

Ken Davitian

Laboratory Worker #2

Ernie Grunwald

David S. Lee

Laboratory Worker #3

Regan Burns

Dalip Singh

CIA Agent

Vincent M. Ward

Geoffrey Pierson

Bill Romanowski

Dancer (uncredited)

Alexandra Nicole Hulme

Lab Worker (uncredited)

Caroline Pho

Embassy Guard (uncredited)

Poco Zocko