Frank Darbo

Rainn Wilson

Libby/Boltie

Elliot Page

Sarah Darbo

Liv Tyler

Jacques

Kevin Bacon

Abe

Michael Rooker

Hamilton

Andre Royo

The Holy Avenger

Nathan Fillion

Detective John Felkner

Gregg Henry

Sgt. Fitzgibbon

William Katt

Toby

Sean Gunn

Quill

Stephen Blackehart

Mr. Range

Don Mac

Voice Of God (voice)

Rob Zombie

Pet Store Employee

Linda Cardellini

Cop

Gerardo Davilla

Cop

Gerardo Davila

Young Frank

Grant S. Goodman

Frank Sr.

Paul Taylor

Teenage Frank

Connor Day

Demonswill

James Gunn

Holly

Mikaela Hoover

Jim

Nick Holmes

Jesus / Guy In Line

Matt Moore

Comic Book Store Jerk

Steve Agee

Librarian

Laurel Whitsett

Passenger Teen

Nate Rubin

Passenger Teen

James Lentzsch

Nathaniel

Edrick Browne

Purse-Snatcher

Danny Cosmo

Wheelchair Woman

Krystal Mayo

Chickenhawk

Russell Towery

Chicken

Mario Jimenez

Transvestite

Jonathan Winkler

Sarah's Sister

Mollie Milligan

Chicken

Mario Jiminez Jr.

Newscaster

Gerry May

Line Butter

Valentine Miele

Line Butter's Girlfriend

Michelle Gunn

Waitress

Darcel Moreno

Long-Haired Hood

Greg Ingram

Libby's Friend

Lindsey Soileau

Waitress

Darcel White Moreno

Christian

Brandon Belknap

Jerry

Zach Gilford

Libby's Friend

Lindsay Soileau

911 Man

Lloyd Kaufman

Range's Technician

Tim J. Smith

Thug Jumped on by Boltie

Mark De Alessandro

Thug Set on Fire

Cole McKay

Thug #1

Dominic Labanca

Thug Missing Arms

John W. Lawson

Thug #1

Dominick LaBanca

Stoner Girl

Christine Quinn

Stoner Girl

Christine Bently