Barney Panofsky

Paul Giamatti

Izzy Panofsky

Dustin Hoffman

Miriam

Rosamund Pike

2nd Mrs. "P"

Minnie Driver

Clara 'Chambers' Charnofsky

Rachelle Lefevre

Boogie

Scott Speedman

Blair

Bruce Greenwood

Constable O'Hearne

Mark Addy

Charnofsky

Saul Rubinek

Solange

Macha Grenon

Michael Panofsky

Jake Hoffman

Kate Panofsky

Anna Hopkins

Leo

Thomas Trabacchi

2nd Mrs. P's Father

Harvey Atkin

2nd Mrs. P's Mother

Linda Sorensen

Cedric

Cle Bennett

Girl at Cafe

Brittany Drisdelle

Rome Doctor

Massimo Wertmüller

Uncle Irv

Howard Jerome

Constable O'Malley of the North

Paul Gross

Wedding Guest

Maury Chaykin

Bartender at Wedding

Larry Day

O'Malley Director #1

Atom Egoyan

O'Malley Director #2

David Cronenberg

T / U Productions Executive #1

Mark Camacho

Dr. Morty

Harry Standjofski

Maître'D at Ritz

George Henri Denis Arcand Arcand

Train Conductor

Ted Kotcheff

The Countess

Marica Pellegrinelli

Judge at Rome Wedding

Domenico Minutoli

Fundraising Target #1

Sam Stone

T / U Productions Executive #1

David Pryde

Fundraising Target #2

Burney Lieberman

Bartender at Grumpy's

Paula Jean Hixson

The 2nd Mrs. P's Housekeeper

Pauline Little

Mover #1

Moe Jeudy-Lamour

Fundraising Target #3

Morty Bercovitch

Wedding Guest

Robin Kazdan

Rabbi

Len Richman

Anna Rose Hopkins

Rabbi's Wife

Sheila Hymans

Production Assistant

Kyle Switzer

Receptionist #1

Rebecca Croll

NY Restaurant Waiter

Steve Bienstock

Notary

Arthur Holden

Young Michael Panofsky

Zack Kifell

Young Kate Panofsky

Simone Richler

Mr. Dalhousie

Arthur Grosser

Woman at Cemetery

Pascale Bourbeau

Massage Parlour Madame

Ellen David

Masseuse

Katia Di Perna

Leo's Girlfriend

Marina Eva

Barney's One Night Stand

Sandra Lavoie

Receptionist #2

Ivana Shein

O'Malley's New Co-Star

Mélanie St-Pierre

Reporter

Tarah Schwartz

Pathologist

Richard J. Lewis

Cousin Jeff

Howard Rosenstein