Jerome

Max Minghella

Audrey

Sophia Myles

Professor Sandford

John Malkovich

Jonah

Matt Keeslar

Jimmy

Jim Broadbent

Sophie

Anjelica Huston

Vince

Ethan Suplee

Bardo

Joel David Moore

Broadway Bob D'Annunzio

Steve Buscemi

Marvin Bushmiller

Adam Scott

Matthew

Nick Swardson

Mikey

Chris McKenna

Lonny

Marshall Bell

Kevin

Marc Vann

Professor Larry Okamura

Jack Ong

Candace

Kate Moennig

Prof. Pidgeon

Charles Schneider

Beat Girl

Lauren Lee Smith

Army-Jacket

Scoot McNairy

Jason

Charlie Talbert

Eno

Jeremy Guskin

David Timlin

Jeff LeBeau

Flower

Monika Ramnath

Shilo

Jeanette Brox

Hurst

Jesse Flanagan

Kiss-Ass

Isaac Laskin

Martel Drinker

Mike Stanley

Cliffy

Brian Turk

Vegan

Finneus Egan

Filthy-Haired Girl

Shelly Cole

Mom

Jean St. James

Donald Baumgarten

Michael Shamus Wiles

Preppy Girl

Cristen Coppen

Professor David Zipkin

Paul Collins

Leslie, Male Model

Ezra Buzzington

Suburban Girl

Kimi Reichenberg

Cranky Guard

Richard Bakalyan

Richard Natwick

Travis Walck

Nympho

Alex Ryan

Mom Platz

Roxanne Hart

Art Dealer

Michael Lerner

Mrs. Helen Sandiford

Marie L. Bain

Jonah's Wife - Marie

Roxanne Day

Dad Hugh Platz

Osman Soykut

Cynthia Platz

Katija Pevec

Doddering Aunt

Edith Jefferson

Young Jerome

Zach Maurer

Vince's Grandpa

John Bliss

Vince's Editor's Girlfriend

Amy Gross

Nympho Slut

Alexandra Ryan

Hector

Bob Golub

Woman Strangled

Lauren Bowles

Young Jerome

Zachary Maurer

Eugene

Brendan Walsh

Stoob

Brian Geraghty

Cute Girl

Valyn Hall

Cute Girl's Boyfriend

Oliver Ryan Anderson

Coach

Curtis Taylor

Coed

Dawn-Lyen Gardner

Female Student

Alexi Wasser

Kid

Nathaniel Lee Jr.

Teacher

Stacey Travis

Grenadine Woman

Wendy Haines

Punching Bully

Erik Walker

Other Bully

Andre Marcus

Cop

Choice Skinner

Cop

Bob Jennings

Scary Local

Sam Sabbah

Girl Student

Kristin Quick

Director

Terry Zwigoff*

Director

Terry Zwigoff