Mary Katherine Gallagher

Molly Shannon

Sky Corrigan/Jesus

Will Ferrell

Evian Carrie Graham

Elaine Hendrix

Eric Slater

Harland Williams

Father Tylenol Ritley

Mark McKinney

Dylan Schmultz-Plutzker

Tom Green

Grandma Gallagher

Glynis Johns

Helen Lewengrub

Emmy Laybourne

Howard

Jason Blicker

Father John

Gerry Bamman

Maria

Jennifer Irwin

Thomas

Rob Stefaniuk

Autumn

Natalie Radford

Summer

Karyn Dwyer

Owen

Chuck Campbell

Mr. Feinstein

Jack Newman

Mrs. Corrigan

Donna Hanover

Freaky Freddy

Don Redican

Freaky Freddy

Dan Redican

Crucifix Nun

Joan Massiah

Moira McDaniels

Jean Howell

George

Frank Scott

Little Mary

Mallory Margel

Thornton Gallagher

Aidan Kelly

Rosemary Gallagher

Deirdre McCloskey

Sister Eileen

Jane Moffat

Father David

David Warrack

Sister Anne

Tracy Wright

Little Boy Slater

Robert Clark

Weatherman

Boyd Banks

Student (uncredited)

Joanna Bennett

Reporter

Rick Campanelli

Choral Singer (uncredited)

Spencer Humm

Reporter

Ariel Manson-Wagner

Bike Boy (uncredited)

Fraser McGregor

Tom, Whose Dad Is Dead (uncredited)

Jonathan Gabriel Robbins

Special Ed Kid

Sal Scozzari

Man in Pink Tutu (uncredited)

Jason Sehorn

Special Ed Kid

Christina Gordon

Special Ed Kid

Susie Dias

Special Ed Kid

David Meinke

Cheerleader

Tina Campbell

Cheerleader

Christine Nowland

Cheerleader

Carol MacKereth

Shamus O'Shea

Michael McCloskey

Una O'Shea

Siobhan Donaghy

Man with Cake

Blake Brooker

Todd (uncredited)

Gabriel Burrafato

Etiquette Record (voice) (uncredited)

Phil Crowley

Dancer (uncredited)

April Morgan