The sinister Dr. Phibes (Vincent Price) has returned and is once again determined to resurrect his deceased wife. Assisted by the beautiful Vulnavia (Valli Kemp), Phibes must retrieve a set of ancient scrolls before he can complete his plan, leading to a trek across Egypt. Among those crossing the villain's path is Darius Biederbeck (Robert Quarry), an explorer who seeks immortality. Phibes plots the deaths of his pursuers, making sure that they are dispatched in unusual and gory ways.