Jon Arbuckle

Breckin Meyer

Garfield (voice)

Bill Murray

Liz

Jennifer Love Hewitt

Happy Chapman/Walter J. Chapman

Stephen Tobolowsky

Wendell

Evan Arnold

Louis

Nick Cannon

Christopher Mello

Mark Christopher Lawrence

Persnikitty

Alan Cumming

Mrs. Baker

Eve Brent

Spanky (voice)

Jimmy Kimmel

Nermal

David Eigenberg

Luca

Brad Garrett

Arlene (voice)

Debra Messing

Cop

Jerry Hauck

Dad Rat (voice)

Richard Kind

Miss Ace Hardware

Vanessa Christelle

Miss Ace Hardware

Vanessa Campbell

Announcer

Daamen J. Krall

Kid Rat (voice)

Alyson Stoner

Dog Owner #1

Rufus Gifford

Dog Owner #2

Randee Reicher

Dog Owner #4

Susan Moore

Roy the Lodge Member

Bill Hoag

Deputy Hopkins

Michael Monks

Older Man

Ben Kronen

Security Officer

Mel Rodriguez

Little Girl

Juliette Goglia

Dog Owner #3

Ryan McKasson

Frank

Joseph Edward Taylor

Pet Monkey (uncredited)

Crystal the Monkey

Steward

Evan Helmuth

Information Agent

AnnaLea Rawicz

News Reporter

Leyna Nguyen

Engineer #2

Frank Payne

Engineer #3

Joe Ochman

Older Woman

Danna Hansen

Larry

John F. Schaffer

Technician

Joe Towne

Little Girl's Dad

Joseph Hale

Thomas Gottschalk

Dorkas Kiefer

Debra Jo Rupp

Alec Sokolow

Virginie Efira

Alexis Victor

Perette Pradier

Bernard Alane

The Rat

Mo'Nique