George Herman "Babe" Ruth

William Bendix

Claire "Hodgson" Ruth

Claire Trevor

Brother Matthias

Charles Bickford

Phil Conrad

Sam Levene

Miller "Hugh" Huggins

Fred Lightner

Jack Dunn

William Frawley

Nightclub Singer

Gertrude Niesen

Babe Ruth as a Boy

Bobby Ellis

Western Union Boy

Stanley Clements

Gambler Dalton

Lloyd Gough

Colonel Jacob Ruppert

Matt Briggs

Dr. Menzies

Paul Cavanagh

Bill Carrigan

Pat Flaherty

Boston Braves' Rookie

Warren Douglas

The Kid

Tony Taylor

Boston Braves' coach

Richard Lane

Mark Koenig

Mark Koenig

Sports Announcers

Melvin Allen

Umpire Ziggy Sears

Ziggy Sears

Sports Announcer

Harry Wismer

Bucky Harris - Baseball Player

Bucky Harris

Sports Announcer

Mel Allen

Reporter

Johnny Grant

News Announcer

H.V. Kaltenborn

Narrator

Knox Manning

Barfly (uncredited)

Al Bain