Frank

Henry Fonda

Jill McBain

Claudia Cardinale

Harmonica

Charles Bronson

Cheyenne

Jason Robards

Brett McBain

Frank Wolff

Morton - Railroad Baron

Gabriele Ferzetti

Sheriff

Keenan Wynn

Sam

Paolo Stoppa

Frank's Gunman

Woody Strode

Wobbles (uncredited)

Marco Zuanelli

Frank's Gunman

Jack Elam

Barman

Lionel Stander

Knuckles

Al Mulock

Jim - Member of Frank's Gang

John Frederick

Timmy McBain (uncredited)

Enzo Santianello

Timmy McBain

Enzo Santaniello

Harmonica as a Boy

Dino Mele

Older Sheriff's Deputy

Luigi Ciavarro

Benito Stefanelli

Bit part

Livio Andronico

Member of Cheyenne's Gang

Salvo Basile

Member of Cheyenne's Gang

Salvatore Basile

Member of Frank's Gang Playing Poker

Aldo Berti

Marilu Carteny

Member of Frank's Gang

Spartaco Conversi

Hired Gun on Train

Saturno Cerra

3rd Member of Cheyenne's Gang

Bruno Corazzari

Member of Frank's Gang in Flashback

Don Galloway

Frank's Lieutenant

Michael Harvey

Member of Frank's Gang in Flashback

Robert Hossein

Girl at Flagstone Station

Raffaella Leone

Member of Frank's Gang in Flashback

Frank Leslie

Harmonica's Brother

Claudio Mancini

Renato Pinciroli

Conrado Sanmartin

Member of Frank's Gang Smoking Pipe at Auction

Frank Braña

Director

Sergio Leone