When his shoe-designer wife, Lisa (Laura Linney), disappears while on one of her frequent business trips, computer executive Peter (Liam Neeson) stumbles upon evidence that she has been having an affair with the dashing Italian Ralph (Antonio Banderas). Impulsively flying to Milan to search for his wife despite the pleadings of their college-age daughter, Abigail (Romola Garai), Peter enters into a complicated charade by befriending Ralph and slowly teasing information about Lisa out of him.