Pressured by long hours filled with life-and-death decisions, medical intern George Ferguson (Clark Gable) grows increasingly exhausted and unsure about his career. After a night call forces him to break another date with fiancée Laura Hudson (Myrna Loy), George takes comfort with nursing student Barbara Dennin (Elizabeth Allan) -- unaware that his mentor, Dr. Hochberg (Jean Hersholt), knows of the liaison. Later, when confronted by Barbara's botched abortion, George must decide his future.