Mandy/Madroid/Milkshakes
Grey DeLisle
Billy / Billybot / Harold / Pale Ghoulish Juror / Chippy the Squirrel (voice) (as Richard Horvitz)
Richard Steven Horvitz
Grim/Sperg/Pirate No. 6
Greg Eagles
Irwin/Pirate No. 5/Unicorn
Vanessa Marshall
I'll Cut You Guy / Pirate #2 / Horrorbot / Burnt Skeleton Guard (voice)
Maxwell Atoms
Peequay
George Ball
I'll Cut You Guy/Pirate No. 2/Horrorbot
Maxwell Atoms
Creeper
Greg Ellis
Bride of Frankenstein
Jane Carr
Giant Cyclops
Bart Flynn
Fred Fredburger
C. H. Greenblatt
Judge Roy Spleen
Phil LaMarr
Horror
George Segal
Fred Fredburger / Pirate #4 (voice)
C.H. Greenblatt
Billy's Mom (voice)
Jennifer Hale
Boogey Man
Fred Willard
General Skarr
Armin Shimerman
Older Irwin (voice)
Dorian Harewood
Miniature Cyclops
Billy West*
2 Headed Parrot (voice)
Rachael MacFarlane
Executioner / Pirate #1 (voice)
James Silverman
Numbuh Three (voice)
Lauren Tom
Pirate #8 / Miniature Cyclops / Spider Clown Mailman / Beast Master (voice)
Billy West
Director
Russell Calabrese
Director
Robert Alvarez
Director
Shaun Cashman
Director
Mike Lyman
Director
Russell Calabrase
Director
Phil Cummings
Director
Matt Engstrom
Director
Eddy Houchins
Director
Gordon Kent
Director
Christine Kolosov
Director
Sue Perrotto
Director
Kris Sherwood
Director
Juli Hashiguchi
Director
Michel Lyman
Director
Juli Murphy