Lincoln Rhyme

Denzel Washington

Amelia Donaghy

Angelina Jolie

Thelma

Queen Latifah

Captain Howard Cheney

Michael Rooker

Detective Kenny Solomon

Michael McGlone

Eddie Ortiz

Luis Guzman

Richard Thompson/Marcus Andrews

Leland Orser

Dr. Barry Lehman

John Benjamin Hickey

Steve, Amelia's Boyfriend

Bobby Cannavale

Detective Paulie Sellitto

Ed O'Neill

Gas Worker

Larry Day

Lieutenant Carl Hanson

Richard Zeman

Lindsay Rubin

Olivia Birkelund

Alan Rubin

Gary Swanson

Train Engineer

James Bulleit

Grandfather

Frank Fontaine

Granddaughter

Zena Grey

NYU Student

Daniel Brochu

Taxi Inspector

Desmond Campbell

Homicide Detective

Peter Michael Dillon

Young Boy

Christian Veliz

Ortiz's Assistant

Ted Whittall

Ortiz's Mother

Mercedes Gómez

Uniform Cop

Anderson C. Bradshaw

Uniform Cop

Andy Bradshaw

Gas Worker

Steve Adams

Girlfriend in Nightclub

Mary C. Hammett

Girl in Nightclub

Amanda Gay

Girlfriend in Nightclub

Mary Hammett

Police Instructor

Burke Lawrence

Cop in Apartment

Terry Simpson

Cop in Apartment

Eric Davis

Bookstore Clerk

Arthur Holden

Rhyme's Sister

Yahsmin Daviault

Rhyme's Niece

Keenan MacWilliam

Rhyme's Sister

Yashmin Daviault

Amelia's Partner

David Warshofsky

Hot Dog Vendor

Mateo Gómez

Male Detective

Jonathan Stark

Forensics Expert

Fulvio Cecere

Fingerprint Cop

Hal Sherman

Forensics Worker

Russell Yuen

Rescue Worker

Jean-Marc Bisson

Rescue Worker

Christopher Bregman

Nurse

Sonya Biddle

Customer in Antique Bookshop (uncredited)

Phillip Noyce

News Reporter (uncredited)

Charles Alonso

NYPD Officer (uncredited)

Michael Arthur

Rescue Worker (uncredited)

Alex Lorre

Cop (uncredited)

Todo Segalla

Perp (uncredited)

Andrew Semple