Dr. Heywood Floyd

Roy Scheider

Dr. Walter Curnow

John Lithgow

Tanya Kirbuk

Helen Mirren

Dr. R. Chandra

Bob Balaban

Dave Bowman

Keir Dullea

HAL 9000 (voice)

Douglas Rain

Caroline Floyd

Madolyn Smith

Dimitri Moisevitch

Dana Elcar

Dr. Vladimir Rudenko

Savely Kramarov

Christopher Floyd

Taliesin Jaffe

Victor Milson

James McEachin

Betty Fernandez, Bowman's Wife

Mary Jo Deschanel

Maxim Brajlovsky

Elya Baskin

Dr. Vasili Orlov

Oleg Rudnik

Irina Yakunina

Natasha Schneider

Yuri Svetlanov

Vladimir Skomarovsky

Irina Yakunina

Natasha Shneider

Mikolai Ternovsky

Victor Steinbach

Alexander Kovalev

Jan Triska

SAL 9000 (voice)

Candice Bergen

Jessie Bowman

Herta Ware

Dr. Hirsch

Robert Lesser

Commercial Announcer

Gene McGarr

Dr. Vladimir Rudenko

Saveliy Kramarov

Anchorman on TV

Larry Carroll

Nurse

Cheryl Carter

Hospital Neurosurgeon

Ron Recasner

Commercial Announcer

Delana Michaels

Man on Park Bench (uncredited)

Arthur C. Clarke

Penny Perry