Machete Cortez

Danny Trejo

Luz/Shé

Michelle Rodriguez

Luther Voz

Mel Gibson

Madame Desdemona

Sofía Vergara

Mendez

Demián Bichir

Miss San Antonio

Amber Heard

La Chameleón

Lady Gaga

El Camaleon 4

Antonio Banderas

Sartana Rivera (uncredited)

Jessica Alba

El Camaleon 2

Cuba Gooding Jr.

Mr. President

Charlie Sheen

El Camaleon 1

Walt Goggins

Sheriff Doakes

William Sadler

Zaror

Marko Zaror

Osiris Amanpour

Tom Savini

Cereza Desdemona

Vanessa Hudgens

KillJoy

Alexa PenaVega

Nurse Lisa

Elise Avellan

Nurse Mona

Electra Avellan

Clebourne

Samuel Davis

Chepo

Julio Oscar Mechoso

Space Babe

Callie Hernandez

Trailer Voice Guy

Corey Burton

Billy Blair

Billy Blair

Elon Musk

Elon Musk

Lieutenant Brass

Jason Christopher

Doc Felix

Felix Sabates

Doctor Villachez

David C. Heard

Messenger

Carlos Rodriguez*

Radio Announcer (voice)

Juan Zuani

Nurse Fine

Marci Madison

Pris

Emmy Robbin

Man in Bondage

Jimmy Gonzales

Man in Bondage

Jimmy Gonzalez

Boss of Mendez

Alejandro Antonio

Bartender Carlos

Pablo Bracho

Wife of Mendez

Crystal Martinez

Male Tourist

Ashley Wood

Female Tourist

Patricia Vonne

Female Tourist

Patricia Vonne Rodriguez

Cabrito Cook

Vincent Fuentes

Police Captain

Rick Delgado

Elderly Attendant

Daniel Arellano

Elderly Attendant

Dan Arellano

Cartel Leader

Sam Medina

Dollface

Elle LaMont

Doctor Goodbar

Eduardo Rentaria

Grasa

Pablo Esparza

Stuttering Tito

Robert Tamayo

Doc Felix

Feliz Sabates

Estoban

Edgar Arreola

Estoban

Adgar Arreola

Dying Cartel Guy

Jorge A. Jimenez

Cartel Leader

Samuel Medina

Voz's Henchman (uncredited)

J.J. Perry

Radio Guest (uncredited)

Alexander Rodnyansky