People are attacked by rats on an extremely hot day in New York City. Meanwhile, ex-boxer Clutch (Nick Damici) is about to be evicted from his apartment in a crumbling tenement building. But, as people begin dying from the rat bites, panic spreads throughout the city, and Clutch is attacked by a mutated human/rat zombie. Clutch and his neighbors lock down their building in an attempt to survive the escalating rat-borne pandemic as New York is quarantined.