Vetri / Dr. Maaran / Vetri Maaran (Thalapathy)

Vijay

Tara, a media anchor and Maaran's love interest

Samantha Ruth Prabhu

Daniel Arockiaraj

S. J. Suryah

Dr. Anu Pallavi "Pallavi", a doctor and Vetri's love interes

Kajal Aggarwal

Aishwarya Vetrimaaran "Ice"

Nithya Menen

S.J. Surya

Vadivu, Maaran's compounder and Vetri's assistant

Vadivelu

Dr. Daniel Arockiyaraj

S. J. Surya

Rathnavel "Randy", Tamil Nadu Police Officer

Sathyaraj

Sarala, Vetri's foster mother

Kovai Sarala

Health Minister

Rajendran

Maniyan

Sathyan Sivakumar

Maniya, Rathnavel's assistant

Sathyan

Anu Pallavi's friend

Shivani Murali

Tara's friend and a media anchor

Misha Ghoshal

Dr. Arjun Zachariah, Daniel's accomplice

Hareesh Peradi

Nolan, Tara's Assistant

Yogi Babu

Tara's mother

Mamilla Shailaja Priya

Cheenu Mohan

Auto Driver / Rickshaw Driver

Kaali Venkat

a Nurse

Devadarshini

Selvi, Auto driver's wife

Senthikumari

a Nurse

Surekha Vani

Salim Ghosh, a magician and foster father of Vetri and Vadiv

Sangili Murugan

a Prisoner

Boxer Dheena

Kaasi

M.Kamaraj

young Maaran

Master Akshath

young Vadivu

Raj Manickam

Vetri Maaran's friend

Abdool

a Doctor

Shankar Sundaram

Kumar, Hospital HR

Pasanga Sivakumar

an airport officer

VJ Shana Mahendran

Sheshadri

Giri Thirumalachari

Kasi, Daniel's henchman

M. Kamaraj

a Police inspector

Rock Prabhu

a Police inspector

Robo Chandru

himself

Gopi

himself

Sudhakar