Earl Partridge

Jason Robards

Rose Gator

Melinda Dillon

Linda Partridge

Julianne Moore

Jimmy Gator

Philip Baker Hall

Phil Parma

Philip Seymour Hoffman

Stanley Spector

Jeremy Blackman

Frank T.J. Mackey

Tom Cruise

Luis Guzman

Luis Guzman

Donnie Smith

William H. Macy

Claudia Wilson Gator

Melora Walters*

Jim Kurring

John C. Reilly

Rick Spector

Michael Bowen*

Claudia Wilson Gator

Melora Walters

Burt Ramsey

Ricky Jay

Rick Spector

Michael Bowen

Gwenovier

April Grace

Thurston Howell

Henry Gibson

Cynthia

Felicity Huffman

Dixon

Emmanuel L. Johnson

Dixon

Emmanuel Johnson

Alan Kligman

Michael Murphy

Dr. Landon

Don R. McManus

Mary

Eileen Ryan

Dick Jennings

Danny Wells

Solomon Solomon

Alfred Molina

Worm

Orlando Jones

Sir Edmund William Godfrey/Young Pharmacy Kid

Pat Healy

Burt Ramsey/Prologue Narrator

Ricky Jay

Todd Geronimo

Patrick Warren

Mrs. Godfrey

Genevieve Zweig

Joseph Green

Mark Flannagan

Mim

Patricia Forte

Stanley Berry

Neil Flynn

Marcie

Cleo King

Daniel Hill

Rod McLachlan

Firefighter

Allan Graf

Chad (voice)

Paul F. Tompkins

Delmer Darion

Patton Oswalt

Avi Solomon

Miguel Pérez

Reno Security Guard

Raymond 'Big Guy' Gonzales

Brad the Bartender

Craig Kvinsland

Craig Hansen

Brad Hunt

WDKK Floor Director

Clark Gregg

Forensic Scientist

Jim Meskimen

Sydney Barringer

Chris O'Hara

Arthur Barringer

Clement Blake

Joseph Green

Mark Flanagan

1958 Detective

Frank Elmore

1958 Policeman

John Kraft Seitz

Young Boy

Cory Buck

Infomercial Guy

Tim 'Stuffy' Sorenen

Middle Aged Guy

Jim Ortlieb

Jimmy's Showgirl

Holly Houston

Little Donnie Smith

Benjamin Niedens

Dentist Nurse No. 1

Veronica Hart

Dentist Nurse No. 2

Melissa Spell

Dr. Lee

James Kiriyama-Lem

Pedestrian No. 1

Jake Cross

Infomercial Guy

Tim Soronen

Pedestrian No. 2

Charlie Scott

Nurse Juan

Juan Medrano

Police Captain

John Pritchett

Young Jimmy Gator

Thomas Jane

Captain Muffy

Michael Shamus Wiles

Doc

Jason Andrews

Cameraman

John S. Davies

Geoff/Seminar Guy

Kevin Breznahan

Dentist Nurse #2

Missy Spell Tanner

Coroner Man

David Masuada

Officer No. 1

Neil Pepe

Pedestrian #1

Jason "Jake" Cross

Detective

Lionel Mark Smith

Coroner Woman

Annette Helde

Librarian

Lynne Lerner

WDKK Page No. 1

Scott Burkett

Richard's Dad

Bob Brewer

Richard's Mom

Julie Brewer

Julia's Mom

Nancy Marston

Julia's Dad

Maurey Marston

WDKK P.A.

Jamala Gaither

WDKK Page No. 2

Amy Brown

Janet (voice)

Mary Lynn Rajskub

Dr. Diane

Meagen Fay

Coroner Man

David Masuda

Cocktail Waitress

Patricia Scanlon

Julia

Natalie Marston

Richard

Bobbie Brewer

Old Pharmacist

Art Frankel

Officer No. 2

Matt Gerald

Pink Dot Guy

Guillermo Melgarejo

Chad

Paul F. Thompkins

Smiling Peanut Patron No. 1

Jim Beaver

Smiling Peanut Patron No. 2

Ezra Buzzington

Smiling Peanut Patron No. 3

Denise Woolfork

WDKK Show Director

Bob Downey Sr.

Pink Dot Girl (voice)

Virginia Pereira

WDKK Director's Assistant

William Mapother

WDKK Medic

Larry Ballard

Richard

Bobby Brewer

Mackey Disciple Twin No. 1

Brett Higgins

Mackey Disciple Twin No. 2

Brian Higgins

Mackey Disciple In Middle

Michael 'Jocco' Phillips

Donnie's Old Neighbor

Lillian Adams

Paramedic No. 1

Steven Bush

Paramedic No. 2

Mike Massa

Paramedic No. 3

Dale Gibson

ER Doctor

Scott Alan Smith

Harmonica Players

New World Harmonica Trio

John Reilly

WDKK Show Director

Robert Downey Sr.

Mackey Disciple in Middle

Michael Lee Phillips Jr.

Miriam Margolyes

Director

Melora Walters*

Director

April Grace

Director

Jason Robards

Director

John Reilly

Director

Tom Cruise

Director

Paul Thomas Anderson

Director

Philip Baker Hall

Director

Philip Seymour Hoffman