Osmosis Jones (voice)

Chris Rock

Leah

Brandy

Frank

Bill Murray

Mrs. Boyd

Molly Shannon

Thrax (voice)

Laurence Fishburne

Drix (voice)

David Hyde Pierce

Bob

Chris Elliott

Mayor Phlegmming (voice)

William Shatner

Shane Detomello

Elena Franklin

Additional Character Voice (voice)

Mickie McGowan

Zookeeper Superintendent

Danny Murphy

Kidney Rock

Uncle Kracker

Additional Character Voices

Carlos Alazraqui

Tom Colonic (voice)

Ron Howard

Additional Character Voices

Rodger Bumpass

(voice)

Sherry Lynn

Additional Character Voices

Richard Horvitz

Additional Character Voices

Danny Mann

Kidney Rock

Kid Rock

Ken Olson

Police Officer

Brian Mone

Mickie T. McGowan

Hector Mercado

Zoo Visitors & Staff

Bob O'Brien

Anne Lockhart

Nurse #2

Nikki Tyler-Flynn

Paul Tuerpé

Keri Tombazian*

Steve Susskind

Robert Wisdom

Chris Phillips

Paul Pape

Emergency Room Doctor #3

Zak Penn

Marilyn Pasekoff

Herschel Sparber

Doug Stone

Al Rodrigo

Pea Soup Staff

Bo Cleary

Paul Christie

Bikini Gang

Docky

Science Fair Contestant

Laura Dunn

Oyster Boy

Willy Dunn

Zoo Visitors & Staff

Helen Britten

Emergency Room Doctor #1

Zen Gesner

Police Officer

Sean Fitzgerald

Pea Soup Manager

John-Eliot Jordan

Emergency Room Doctor #2

Marc Hyman

School Janitor

Jackie Flynn

Dreamy Photographer

Sean Gildea

Nurse #3

Elizabeth Jordan

Rif Hutton

Sally Ann Brooks

Antonio Fargas

Art Kimbro

Donald Fullilove

The Chief

Joel Silver

Janis Dardaris

Eddie Barth

Eddie Frierson

Jackie Gonneau

Jonathan Adams