William Thomas Green Morton

Joel McCrea

Elizabeth Morton

Betty Field

Professor John C. Warren

Harry Carey

Eben Frost

William Demarest

Dr. Horace Wells

Louis Jean Heydt

Dr. Charles T. Jackson

Julius Tannen

Vice-President of Medical Society

Edwin Maxwell

President Franklin Pierce

Porter Hall

Dr. Heywood

Franklin Pangborn

Homer Quinby

Grady Sutton

Betty Morton

Donivee Lee

Judge Shipman

Harry Hayden

Dr. Dahlmeyer

Torben Meyer

First Dental Patient

Victor Potel

Senator Borland

Thurston Hall

The Priest

J. Farrell MacDonald

Cashier-Charles

Robert Dudley

Morton's Sign Painter - replaced by Hank Worden (uncredited)

Roscoe Ates

Mr. Abbott

Robert Frandsen

Onlooker (uncredited)

Hank Bell

Young Mother

Sylvia Field

Massachusetts Medical Society Man (uncredited)

Franklyn Farnum

Young Father

Reginald Sheffield

Morton's Clinic Manager (uncredited)

Byron Foulger

Morton's Butler

Robert Greig

Morton's Sign Painter - replaced Roscoe Ates (uncredited)

Hank Worden

Servant Girl

Sheila Sheldon

Presidential Secretary (uncredited)

Arthur Hoyt

Mr. Chamberlain

Harry Rosenthal

Porter

Frank Moran

Whackpot

Sig Arno

Mr. Stone

Al Bridge

Mrs. Whitman

Georgia Caine

Frightened Patient

Chester Conklin

Mr. Burnett

Jimmy Conlin

Wells' Ugly Patient

Esther Howard

Mr. Whitman

Arthur Stuart Hull

Gruber, Glassware Shop Owner

Emory Parnell

Colonel Lawson

Dewey Robinson