Ricardo El Mandril Sanchez

Jesus Christ

Martin Donovan

Magdalena

PJ Harvey

Jose Alvarez

Satan

Thomas Jay Ryan

Dave

Dave Simonds

Joaquin

Channing Tatum

Dave

Davd Simonds

Maria

Zoe Saldana

Manolo

Diego Luna

Edie

Miho Nikaido

Lawyer

D.J. Mendel

Mary Beth

Christina Applegate

Receptionist

Katreen Hardt

Candle Maker

Ice Cube

True Believer

James Urbaniak

La Muerte

Kate del Castillo

Hotel Clerk

Anna Köhler

Martyr

Martin Pfefferkorn

Xibalba

Ron Perlman

Pancho Rodriguez

Cheech Marin

Skeleton George

Plácido Domingo

Waitress

Layla Alexander

Skeleton Carmen

Ana de la Reguera

Computer Wizard

Michael Ornstein

Mormon Thug #1

Paul Albe

Chato

Eugenio Derbez

Mormon Thug #2

Don Creech

Pepe Rodriguez

Gabriel Iglesias

Pablo Rodriguez

Ricardo Sanchez

Man at Airport

Joseph McKenna

Woman at Airport

Abby Royle

Skeleton Luis

Danny Trejo

Elijah Rodriguez

The Salvation Army Band (as Yo La Tengo)

Georgia Hubley

The Salvation Army Band

Yo La Tengo

The Salvation Army Band (as Yo La Tengo)

Ira Kaplan

Young Maria

Genesis Ochoa

The Salvation Army Band (as Yo La Tengo)

James McNew

Orphan

Trey Bumpass

Preacher on Radio (voice)

William S. Burroughs

Chakal

Dan Navarro

Sasha (As Kennedy 'KK' Peil)

Kennedy Peil

Anjelah Johnson-Reyes

Scardelita

Sandra Equihua

Ignacio

Gunnar Sizemore

Sister Ana

Angélica María

Cave Guardian / Father Domingo

Eric Bauza

Claudia

Sandra Echeverría

La Muerte as Old Woman

Tonita Castro

Old Man Hemingway

Troy Evans

Land of the Remembered Captain

Miguel Sandoval

Grandma

Grey DeLisle

Thomas

Aron Warner

Land of the Remembered Captain's Wife

Guillermo del Toro

Conductor

Brad Booker