Herself

Sarah Silverman

Homeless Man (segment "Lisa")

Nathan Barnatt

Girl 5 (segment "Lisa")

Lauren Lapkus

Father (segment "Ham")

John C. Reilly

Herself (segment "Knickers")

Laura Silverman

Officer Durand (segment "Knickers")

Seth Rogen

Mother (segment "Lisa")

Jade Catta-Preta

Girl 2 (segment "Lisa")

Natasha Leggero

Girl 1 (segment "Lisa")

Shelby Fero

Himself (segment "Retro Video Arcade")

Nathan Fielder

Himself (segment "Retro Video Arcade")

David Dineen-Porter*

Self

Kyle Dunnigan

Himself (segment "Lisa")

Michael Daniel Cassady

Himself

Brett Gelman

Girl 6 (segment "Lisa")

Emily Maya Mills

Father (segment "Lisa")

Nick Rutherford

Self

Rob Schrab

Himself (segment "Lisa")

Paul Rust

Self

Stoney Sharp

Mailman

Armen Weitzman

Girl 3 (segment "Lisa")

Kulap Vilaysack

Self

Eric Wareheim

Scientist 1 (segment "CCDF")

Harris Wittels

Self

Lo Mutuc

Girl 4 (segment "Lisa")

Tig Notaro

Self

Todd Glass

Bride 5 (segment "Absorption")

Grace Helbig

Himself (segment "Absorption")

2 Chainz

Bad Guy 2 (segment "CCDF")

Casey Ford Alexander

Tomato Man (segment "Ham")

Jack Bornoff

Cashier (segment "Knickers")

Hailey Boyle

Cooper (segment "Ginger Orphan Playhouse") (voice)

Aaron Chrenen

Lloyd (segment "Absorption")

Larry A. Davies

Groom 2 (segment "Absorption")

Greg Davis Jr.

Madame Trinkett (segment "Ginger Orphan Playhouse") (voice)

Donna DuBain

Bad Guy 1 (segment "CCDF")

Trevor Eyster

Malinda (segment "Ham")

Malinda Farrington*

Prostitute (segment "CCDF")

Kate Freund

Bad Guy 3 (segment "CCDF")

David Garcia

Himself

Cyrus Ghahremani

Bride 4 (segment "Absorption")

Hannah Hart

Customer (segment "Knickers")

Deloris Heard

Pamela (segment "Ham")

Pamela Immel

Band Member 4 (segment "Absorption")

Zack Kennedy

Himself (segment "Absorption")

Keegan-Michael Key

Vacuum Salesman (segment "Ginger Orphan Playhouse") (voice)

Ben Lepley

Cashier (segment "Ham")

Catherine Lydon

Bride 3 (segment "Absorption")

Rasika Mathur

Son (segment "Ham")

Kyle Pacek

Groom 3 (segment "Absorption")

Sandeep Parikh

Self (segment "Absorption")

Jordan Peele

Bride 2 (segment "Absorption")

Issa Rae

Self

Mike Relm

Taco Truck Worker (segment "CCDF")

Willy Roberts

Band Member 2 (segment "Absorption")

Mark Taormino

James (segment "Ham")

James Trenton

Groom 1 (segment "Absorption")

Jack Vale