First gaining notoriety as Sookie on the hit sitcom Gilmore Girls, actress Melissa McCarthy began her onscreen career with a bit part on her cousin's The Jenny McCarthy Show. Minor film and TV roles followed before she landed the aforementioned part of Sookie St. James, a role she would play throughout Gilmore Girls seven-season run on The WB/CW. In 2007, McCarthy was cast in a supporting role alongside Christina Applegate on the ABC comedy Sam I Am.

She found genuine success with the sitcom Molly and Me, playing one-half of a weight-challenged couple opposite Billy Gardel and earning an Emmy nod for Best Actress in a Comedy Series. However, it was her supporting turn in the R-rated comedy Bridesmaids that brought her a taste of mass adulation as well as an Oscar nomination for Best Supporting Actress.