Samantha

Christina Applegate

Andrea Belladonna

Jennifer Esposito

Howard

Kevin Dunn

Dena

Melissa McCarthy

Frank

Tim Russ

Regina Newly

Jean Smart

Todd

Barry Watson

Winston Funk

Timothy Olyphant

Chase Chapman

Rick Hoffman

Chloe

Kiele Sanchez

Craig

Jerry O'Connell

Jason

Ryan Carlberg

Nathan

Todd Grinnell

Rene

William Abadie

Valerie

Jessica St. Clair

Young Samantha

Kelsey Smith

Woman

Soledad Campos

Audrey Rhodes

Beth Littleford

Nurse

Melody Butiu

AA Leader

Brett Rickaby

Paul

Gerald Downey

Man

Tony Winters

Teenage Samantha

Johanna Braddy

Tracy

Joy Osmanski

Ryan

Rand Holdren

Guest Star

Dean Cochran

Orderly

Brian Catalano

Flower Delivery Guy

Reggie Jordan

Rory

Gerard Sanders

Driver

Ossie Mair

Woman Protestor

Morgan Murphy

Young Woman

Sarah Spiegel

Trey Wells

Curt Cornelius

Dr. Kegoshian

Frank Maharajh

Kid

Jagger Chase

Kevin

Eddie Cibrian

Hypnotherapist

Joy Lofton

Dr. Kerry Hall

Nakia Burrise

Police Sergeant

Tony Jones

Russ

Timon Kyle Durrett

Paul's Wife

Amanda Young

Cashier

Marilyn Sue Perry

Sign Language Interpreter

Jaclyn Kerhulas

Woman Customer

Natasha Leggero

Jerri

Dana Sorman

Barista

Adam Jennings

Kissing Couple

Tamas Menyhart

Artist

Jim Rash

Coffee shop clerk

Tom Lenk

Vic

Jamison Haase

Bridesmaid

Kara Taitz

Teenage Samantha 2

Emma Degerstedt

Barista

Arshad Aslam

Lady in the Bar

Isis Harris

Angry Woman

Jelynn Sophia

Bartender

Jarrod Robbins

AA Female Leader

Jill Talley

Hipster

Jonathan Schmock

Waiter

B.J. Clinkscales

Doctor

David Pearl

Wedding Guest

Michael Patrick Breen

Dave

Dan Thiel

Guy

Brandon Ford Green

Real Estate Executive

Aliza Pearl

Cameron

Ian Duncan