Melanie Mayron trained at the American Academy of Dramatic Arts, then studied with Sandra Seacat and Lohn Lehne. She debuted in a touring production of Godspell which ran for three years, and gained a small supporting role in Paul Mazursky's Harry and Tonto (1974). Since then she has divided her time between stage, screen, and TV work. For her performance in Girlfriends (1978), she won the Best Actress Award at the 1979 Locarno Film Festival; also in 1979, she made her New York stage debut, in The Goodbye People. In the late '80s she teamed up with Catlin Adams to write and produce films; their work has included the film Sticky Fingers (1988) and the TV movies Tunes for a Small Harmonica and The Pretend Game. She is best-known as a co-star of the TV series thirtysomething, for which she won an Emmy in 1989.