Jane Villanueva

Gina Rodriguez

Xiomara "Xo" Villanueva

Andrea Navedo

Rafael Solano

Justin Baldoni

Michael

Brett Dier

Petra/Anezka

Yael Grobglas

Alba Villanueva

Ivonne Coll

Rogelio De La Vega

Jaime Camil

Guest Star

Nia Vardalos

Dr. Luisa Alver / Luisa Alver

Yara Martinez

Guest Star

David Bisbal

Rose Solano

Bridget Regan

Narrator (voice)

Anthony Mendez

Dina Milagro

Judy Reyes

Guest Star

Melinda Page Hamilton

Lachlan Moore

Michael Rady

Guest Star

Kathleen Wilhoite

Guest Star

Kathleen York

Nadine Hansan

Azie Tesfai

Lina / Lina Santillan

Diane Guerrero

Emilio Solano

Carlo Rota

Guest Star

Ryan Devlin

Guest Star

Cheech Marin

Roman Zazo / Aaron Zazo

Alano Miller

Guest Star

Priscilla Barnes

Magda

Priscilla Barnes

Guest Star

Mariah Buzolin

Guest Star

Tony Plana

Guest Star

Nilla Watkins

Guest Star

Ava Davila

Guest Star

Nicholas Gonzalez

Elena Di Nola

Fabiana Udenio

Guest Star

Vanessa Vander Pluym

Guest Star

Kristen O'Meara

Guest Star

Nicole J. Butler

Esteban Santiago

Keller Wortham

Guest Star

Paulina Rubio

Guest Star

Andrew J. Lee

Guest Star

Daisy McCrackin

Guest Star

Leslie Simms

Guest Star

Juanes

Guest Star

Tina Casciani

Guest Star

Michael Galante

Guest Star

Rachel DiPillo

Guest Star

Wes Armstrong

Guest Star

Jenna Ortega

Guest Star

David Castaneda

Guest Star

Donnabella Mortel

Guest Star

Christopher Corbin

Guest Star

Rita Moreno

Guest Star

Karl T. Wright

Guest Star

Jane Seymour

Guest Star

Julie Berman

Guest Star

Alex Loynaz

Guest Star

Tammy Caplan

Guest Star

Daniel Kash

Guest Star

Brittani Ebert

Anna

Mia Allan

Guest Star

Willow Geer

Guest Star

Lynn Adrianna

Guest Star

Skylar T. Adams

Guest Star

Brian Dare

Guest Star

Camille Collard

Krishna / Krishna Dhawan

Shelly Bhalla

Ellie / Ellie Solano

Ella Allan

Mateo Solano Villanueva

Elias Janssen

Director

Norma Maldonado

Darcy Factor / Darci Factor

Justina Machado

Jorge / Jorge Garcia

Alfonso Diluca

Production Assistant

Rudy Martinez

Dennis

Christopher Allen

Jane "JR" Ramos / Jane Ramos

Rosario Dawson

Marlene Donaldson

Melanie Mayron

Lieutenant Armstrong

Greg Collins

Teen Xiomara

Catherine Toribio

Susanna Barnett

Megan Ketch

Four-Year-Old Mateo

Joseph Sanders

Little Girl Jane / Young Jane / 7-Year-Old Jane

Lillianna Valenzuela

Chuck

Johnny Messner

Camille Collard

Teenage Jane

Montse Hernandez

Bruce

Ricardo Chavira

Jonathan Chavez

Adam Rodríguez

Derek

Mat Vairo

Fabian

Francisco San Martin

Adam

Tyler Posey

Young Alba

Rosie Garcia

Blanca

Greice Santo

Milos

Max Bird-Ridnell

Sonogram Technician

Vanessa Mizzone

Senior Network Executive

Cate Cohen

Dana

Sheila Carrasco

Valeria

Vanessa Merrell

Victoria

Veronica Merrell-Burriss

Professor Blake

Oliver Vaquer

Adriana Chavando

Angie Cepeda

Patricia Cordero

Molly Hagan

Sonia

Jessica Caban

Catalina

Sofia Pernas

Young Mateo / Mateo Sr.

Dennis Mencia

River Fields

Brooke Shields

Director

Melanie Mayron

Director

Howard Deutch

Director

Elodie Keene

Director

Brad Silberling

Director

Robert Luketic

Director

Debbie Allen

Director

Janice Cooke

Director

Jann Turner

Director

Norman Buckley

Director

Stuart Gillard

Director

Joanna Kerns