Dante (voice)

Johnny Yong Bosch

White Rabbit/News Anchor (voice)

Hoon Lee

Lady (voice) / Mary (voice) / Mary

Scout Taylor-Compton

Vergil(voice)

Robbie Daymond

Baines (voice) / Baines / Demon Soldier (voice)

Kevin Conroy

Arkham / Agni / Rudra (voice)

Ray Chase

Enzo/Officer/Man(voice)

Chris Coppola

Mothe (voice)

Erica Lindbeck

Eva (voice) / Echidna / Demon Girl

Kari Wahlgren

Arius (voice)

Graham McTavish

Baines (voice) / Baines / News Anchor 1 (voice)

Ian James Corlett

Anders (voice) / Anders / Guard (voice)

Benjamin Abiola

Plasma / Griff (voice) / Demon Hunter #1

Roger L. Jackson

Captain / Fury 1 / Call Operator (voice)

Jason Marnocha

Chi / Secretary 1 (voice) / Chi (voice)

Salli Saffioti

Tom / Demon 2 (voice) / Chained Demon 1 (voice)

John Omohundro

Argosax (voice) / Argosax / Guest

Andrew Morgado

Young Vergil (voice) / Young Vergil / Boy (voice)

Marcel Nahapetian

Mattie (voice) / Additional Voices (voice)

Sa'Raya Paris Johnson

Young Dante (voice)

Kue Lawrence

Narrator (voice) / Hobbes / News Anchor 1

Matthew Waterson

Hopper / Protester (voice) / Demon 1 (voice)

Jon Gries

Mushi / Rama (voice) / Fallen

Dee Bradley Baker

King (voice)

Sunkrish Bala

Sentry (voice)

Tina Majorino

Dr. Fisher (voice) / Dr. Fisher / Kurt

Zeke Alton

Patriot (voice) / Patriot / Cop

Leilani Barrett

Ninja / Demon Woman (voice) / Cop (voice)

Fryda Wolff

Radio Host (voice) / Soldier / Analyst

Ryan Colt Levy

Nell Goldstein / Psychiatrist (voice) / Redhead (voice)

Tara Strong

Trismagia / Lead Soldier (voice) / DARKCOM Guard (voice)

Rick D. Wasserman