Nadia Vulvokov

Natasha Lyonne

Maxine

Greta Lee

John

Yul Vazquez

Alan Zaveri

Charlie Barnett

Ruth Brenner

Elizabeth Ashley

Horse

Brendan Sexton III

Lizzy

Rebecca Henderson

Lenora Vulvokov

Chloë Sevigny

Mike Kershaw

Jeremy Bobb

Young Ruth Brenner

Annie Murphy

Vera Peschauer

Irén Bordán

Claire

Jocelyn Bioh

Beatrice

Dascha Polanco

Subway announcer (voice)

Rosie O'Donnell

Ferren

Ritesh Rajan

Ryan

Yoni Lotan

Delia

Athina Papadimitriu

Paramedic

Max Knoblauch

Chez

Sharlto Copley

Agnes

Carolyn Michelle Smith

Derek

Ephraim Sykes

Young Nadia

Brooke Timber

Lucy

Tatiana E. Rivera

Dr. Zaveri

Lillias White

Audrey

Mirirai Sithole

Salim

Anoop Desai

Peter

Stephen Adly Guirgis

Young Vera Peschauer

Ilona McCrea

Dr. Daniel

David Cale

Kamile

Fady Kerko

Shifra

Tami Sagher

Rabbi

Jonathan Hadary

Fred

Branden Wellington

Liana

Stella Schnabel

Bartender

Tawny Sorensen

Joe

Burt Young

Jordana

Charisma Glasper

Young Ruth

Kate Jennings Grant

Lenny

Sandor Funtek

Young Delia

Franciska Farkas

Carnival Barker

Marc Geller

Director

Jamie Babbit

Director

Leslye Headland

Director

Natasha Lyonne