Luke Cage
Mike Colter
Mariah Dillard
Alfre Woodard
Misty Knight
Simone Missick
Claire Temple
Rosario Dawson
Cornell "Cottonmouth" Stokes
Mahershala Ali
Shades
Theo Rossi
Rafael Scarfe
Frank Whaley
John McIver/Bushmaster
Mustafa Shakir
Detective Mark Bailey
Justin Swain
Tilda Johnson
Gabrielle Dennis
Rosalie Carbone
Annabella Sciorra
Sugar
Sean Ringgold
Soledad Temple
Sonia Braga
Willis 'Diamondback' Stryker
Erik LaRay Harvey
Bobby Fish
Ron Cephas Jones
Alex Wesley
John Clarence Stewart
Inspector Priscilla Ridley / Deputy Chief Priscilla Ridley
Karen Pittman
D.W. Griffith
Jeremiah Craft
Zip
Jaiden Kaine
Sheldon Shaw
Kevin Mambo
Anansi
Sahr Ngaujah
Detective Nandi Tyler
Antonique Smith
Comanche
Thomas Q. Jones
James Lucas / James Lucas (voice)
Reg E. Cathey
Captain Tom Ridenhour
Peter J. Fernandez
Auntie Ingrid
Heather Simms
Ben Donovan
Danny Johnson
Thembi Wallace
Tijuana Ricks
Raymond 'Piranha' Jones
Chaz Lamar Shepherd
Domingo Colon
Jacob Vargas
Candace
Deborah Ayorinde
Connie Lin
Jade Wu
Lonnie Wilson
Darius Kaleb
Stephanie aka Billie
Tarah Rodgers
Captain Betty Audrey
Sonja Sohn
Dr. Noah Burstein
Michael Kostroff
Megan McClaren / Megan McLaren
Dawn-Lyen Gardner
Dontrell 'Cockroach' Hamilton
Dorian Missick
Reva Connors
Parisa Fitz-Henley
Goon One / Goon
Jamar Greene
Patricia Wilson
Cassandra Freeman
Turk Barrett
Rob Morgan
Wilfredo 'Chico' Diaz
Brian Marc
Lieutenant Perez
Manny Pérez
Amos
R. Marcos Taylor
Teenage Carl Lucas / Teenage Carl
Clifton Cutrary
Damon Boone
Clark Jackson
Teenage Willis Stryker
Jared Kemp
Sergeant Jacob 'Jake' Smith
Lee R. Sellars
ESU Lieutenant Mario Green
P.J. Marshall
Jin Lin
Clem Cheung
Drea Powell
Michelle Beck
Detective Donnie Chang / Detective Chang
Andrew Pang
D-Nice
D‐Nice
Reporter 1 / Male Reporter / Reporter #1
Tristan Laurence Perez
Aisha Axton
Ninja N. Devoe
Goon Three
Truck Hudson