Following a similar format to a former online show that Tom Green hosted, "Tom Green Live" features the comic interviewing a guest from the entertainment world. Most of the hourlong episodes feature an interview with a single guest who gets grilled by Green and viewers, who are able to ask questions through video chat software. Each episode's initial broadcast airs live, allowing for a deeper look into the guest's life that might not be seen on other talk shows that edit interviews before they air. "Tom Green Live" also features less of a comedic atmosphere than his previous efforts.