Dominick Birdsey/Thomas Birdsey

Mark Ruffalo

Concettina Ipolita Tempesta 'Ma' Birdsey

Melissa Leo

Lisa Sheffer

Rosie O'Donnell

Dr. Patel

Archie Panjabi

Joy Hanks

Imogen Poots

Ray Birdsey

John Proccacino

Dessa Constantine

Kathryn Hahn

Ray Birdsey

John Procaccino

Leo

Rob Huebel

Early Adulthood Dominick Birdsey / Thomas Birdsey

Philip Ettinger

Ralph Drinkwater

Michael Greyeyes

Dessa Constantine (young)

Aisling Franciosi

Shawn Tudesco / Dominick and Thomas Acting Double

Gabe Fazio

Sergeant Mercado

Guillermo Diaz

Young Thomas Birdsey

Rocco Masihi

Domenico Onofrio Tempesta

Marcello Fonte

Young Dominick Birdsey

Donnie Masihi

Ruth Hood

Laura Esterman

Dr. Hume

Bruce Greenwood

Al

Brian Goodman

Nedra Frank

Juliette Lewis

Miss Hanker

Annie Fitzgerald

Henrey Hood / Henrey Rood

Joseph Ragno

Penny Ann Drinkwater

Acahkos Johnson

Marie Sexton

Jaiden Klein

Channy

Charles Reina

Bunny Borsa

Violet Adams

Otero

Oliver Patnode

Young Leo

Matt Helm

17-19 Year Old Dominick & Thomas Acting Double

Derek Goh

Angie Constantine

Agatha Nowicki

Prosperina Tucci

Irene Muscara

Mrs. Birdsall

Adrienne R. Williams

Nabby Drinkwater

Tatanka Means

Tom Stratford

Father Lavie

Harris Yulin

Dr. Yup

Sue Jean Kim

Stuart Feinstein

Michael Simon Hall

Fatso

Michael Armand DeMatteo

Mrs. O'Meara

Gina Costigan

Boyfriend of Dr. Hume's Daughter

Steven Cox

Nabby Drinkwater's Wife

MorningStar Angeline

Ozzie

Reggie Gowland

School Bus Driver

James Quattrochi

Abruzzi

Al Linea

Humanities Department Chair

Christine Parks

Mill Foreman

Richard Fitch

Hospital Aide

Chris Swain

Merciful Mother

Amy Lynn Stewart

Librarian

Marylouise Burke

Nurse

Nacia Walsh

Social Worker at Hatch

Sandra Berrios

Office Buddy

Morgan Sullivan

Kristin

Laura Silverman

ER Patient

Albert Skowronski

Landlubbers (voice)

Jake Robards

Thomas' Surgeon

Michael Genet

Ma's Oncology Nurse

María Gonzalez

Gene Diogenes

A.C. Peterson

Thad

Christopher J. Hanke

Jeanette

Rachel B. Joyce

Support Group Counselor

Paul Coleman

Kyle's Dad

Brandon J. Dirden

Doreen

Katt Masterson

Larry Penn

Jason Furlani

English Professor

Kate Grimes

Brunette

Chelsea Sheets

Nurse

Felix Solis

Steve Falice

Joe Grifasi

Omar

Raymond Neil Hernandez

Vincenzo Tempesta

Simone Coppo

Dr. Yates

Sean Cullen

Nunzio Tucci

Federico Dordei

Charlotte

Shannon Plumb

11 Year Old Concettina

Zaria Degenhardt

Mourner Mark

Mark A. Gamma

Mourner Wayne

Wayne J. Miller

Ray's Orderly

Thomas Gionet-Lavigne

Templeton

Alexander Hacker

Paddy Wagon Officer

Robert Mladinich

Dr. Hume's Daughter

Destry Allyn Spielberg

Ignazia Tempesta

Roberta Riganò

Robocop

Tim Ruddy