Best friends and misfits Fran and Jamie are making their way in the world with only each other to rely on; they also just happen to kill people for a living. Fran and Jamie are not your typical assassins for hire, having accidentally stumbled into a career in contract killing. Their terrifying boss, Mr. K, makes it clear that their lives are at stake if they mess up their assignments. Through frivolous bickering and inane antics, the hapless duo tries to carry out their latest hits without being derailed by their own incompetence. As the pair is thrown into a series of bizarre misadventures, the body count mounts (along with the mishaps). While affable goofball Jamie seems content to spend her days hanging out in a van with her best friend, the neurotic Fran starts to question whether this is really the life she wants, putting their friendship to the test.