Roger Murtaugh

Damon Wayans

Martin Riggs

Clayne Crawford

Dr. Maureen "Mo" Cahill

Jordana Brewster

Trish Murtaugh

Keesha Sharp

Captain Brooks Avery

Kevin Rahm

Bernard Scorsese

Johnathan Fernandez

Sonya Bailey

Michelle Mitchenor

Miranda Riggs

Floriana Lima

Det. Maria Torez

Toni Trucks

Roger Murtaugh Jr.

Dante Brown

Det. Genie Babcock

Sprague Grayden

Riana Murtaugh

Chandler Kinney

Guest Star

Malcolm-Jamal Warner

Guest Star

Hilarie Burton

Guest Star

Lyndon Smith

Daryl Hennicky

Gino Anthony Pesi

Rachel

Elizabeth McLaughlin

Ronnie Delgado

Tony Plana

Alejandro Cruz

Richard Cabral

Oscar Alvarez

Peter Cortes

Guest Star

Scott William Winters

Julian

Tanc Sade

Guest Star

Jason Derulo

Guest Star

Megan Stevenson

Guest Star

Thomas Lennon

Guest Star

Ted Levine

Guest Star

DeRon Horton

Wesley Cole

Seann William Scott

Guest Star

Kristoffer Polaha

Gideon Lyon

Matt Passmore

Guest Star

Chris Tavarez

Dylan Ashworth

Roberto Aguire

Guest Star

Adrian Bustamante

Guest Star

Alejandro Edda

Guest Star

AJ Rivera

Zach Bowman

Andrew Creer

Guest Star

Shashawnee Hall

Guest Star

Jason Rodriguez

Guest Star

Danny Mora

Guest Star

Joyful Drake

Guest Star

Aaron McPherson

Jim McNeile

Andrew Patrick Ralston

Guest Star

Silvia Busuioc

Guest Star

Robert Curtis-Brown

Maria Navar

Daniella Alonso

Guest Star

Casey Kramer

Guest Star

Jeannine Kaspar

Guest Star

Raul Casso

Nathan Riggs

Rex Linn

Guest Star

Alyssa Diaz

Guest Star

Robert Arce

Guest Star

Christopher T. Wood

Molly Hendricks

Kristen Lee Gutoskie

Agent Chappel

Ned Vaughn

Guest Star

Kwame Patterson

Guest Star

Pancho Cardeña

Guest Star

Michael J. Harney

Guest Star

Rick Ravanello

Guest Star

Alex Weed

Guest Star

Gail Borges

Guest Star

Marco Rodríguez

Guest Star

Chin Yere

Guest Star

Golden Brooks

Guest Star

Derek Mio

Guest Star

James Black

Guest Star

Luis Moncada

Guest Star

David Klency

Young Martin Riggs / Young Nathan Riggs / Young Riggs

Chase Mangum

Guest Star

Ellen Hollman

Louisa Gutierrez

Paola Lázaro

Natalie Flynn

Maggie Lawson

Ben

Duncan Joiner

Erica Malick

Nishi Munshi

Gina Santos

Michelle Hurd

Levon Tibibian

Rudolf Martin

Partner

Colin Patrick Lynch

Station Officer

Carl Tart

SWAT Leader

Dutch Johnson

Parking Security Guard

Jeff Houkal

OR Nurse

Britt Sanborn

Race Crewman

Tweed Michael Manning

Christopher Aber