LaDonna Batiste-Williams

Khandi Alexander

Delmond Lambreaux

Rob Brown

L.P. Everett

Chris Coy

Janette Desautel

Kim Dickens

Sofia Bernette

India Ennenga

Sonny

Michiel Huisman

Albert "Big Chief" Lambreaux

Clarke Peters

Toni Bernette

Melissa Leo

Annie Talarico

Lucia Micarelli

Antoine Batiste

Wendell Pierce

Davis McAlary

Steve Zahn

Lt. Terry Colson

David Morse

Aunt Mimi

Elizabeth Ashley

Nelson Hidalgo

Jon Seda

Lanny Fox

Wilson Bethel

C.J. Liguori

Dan Ziskie

Desiree

Phyllis Montana-Leblanc*

Tim Feeny

Sam Robards

Jacques

Ntare Mwine

Himself

Dr. John

Cornell Williams

Cornell Williams

Father Marcus

Eric R. Moreland

Detective Anthony Nikolich

Yul Vazquez

James Woodrow

Jim True-Frost

Henry

Henry Griffin

Creighton Bernette

John Goodman

Mrs. Brooks

Venida Evans

Marvin Frey

Michael Cerveris

Officer Wilson

Lucky Johnson

Linh

Hong Chau

Herself

Debbie Davis

Lula Prichett

Tarra Riggs

Himself

Herlin Riley

Vincent Abreu

Ned Bellamy

Self

Elvis Costello

Herself

Yvette Voelker

Jennifer

Jazz Henry

Self

Lucinda Williams

Derek Watson

Anthony Anderson

Herself

Holley Bendtsen

Davina Lambreaux

Edwina Findley

Guest Star

Cordell Moore

Ramona McAlary

Ann McKenzie

Guest Star

Lee Nguyen

Robert

Jaron Williams

Himself

Donald Harrison Jr.

Dr. Roger McAlary

Marco St. John

Himself

Washboard Chaz Leary

Vice Principal Sonastine

Shanda Quintal

Darnell Nichols

Darien Sills-Evans

Desiree

Phyllis Montana-LeBlanc

Cherise

Camryn Jackson

Guest Star

Eric Frey

Alcide Batiste

Renwick Scott

Randall Batiste

Sean-Michael Bruno

Himself

Ben Nichols

Guest Star

Blake Miller

Liquor Salesman

Al Vicente

Himself

Nicholas Payton

Arnie Reyes

Jeffrey Carisalez

Sandy

Lyndsay Kimball

Himself

Linzay Young

Agt. Collington

Colin Walker

Guest Star

Jonathan Batiste

George Cotrell

Otto DeJean

Guest Star

Daniel Coolik

Himself

Corey Glover

Guest Star

Theresa Andersson

"Memphis" Ronnie

Eddie Vanison

Himself

Big Sam Williams

Robinette

Davi Jay

Herself

Aurora Nealand

Guest Star

Markell Montgomery

Captain Richard LaFouchette

James DuMont

Detective Luis Calderon

J. Omar Castro

Himself

Ellis Marsalis

Himself

Troy "Trombone Shorty" Andrews*

Larry Williams

Lance E. Nichols

Det. Thomas Silby

J.D. Evermore

Himself

Terence Blanchard

Himself

John Boutte

Detective Capell

Dexter Tillis

Mr. Gilday

John Joly

Guest Star

Brandi Coleman

Louise

Nikai Clark

Darren Lecoeur

Keith Hart

Himself

John Cleary

Himself

Kermit Ruffins

Officer Duval

Kelsey Scott

Guest Star

Derrick Tabb

Guest Star

Jacob Kelly

Capt. Jack Maletesta

Tony Senzamici

Himself

Michael Doucet

Himself

Don Bartholomew

Bill Valis

Phil Centanni

Cheri Lambreaux

Tameka Bob

Himself

Louis Michot

Mrs. Gilday

Julie Ann Doan

Donald

Carl J. Walker

Himself

Andre Bohren