Angus "Mac" MacGyver

Lucas Till

Jack Dalton

George Eads

Riley Davis

Tristin Mays

Patricia Thornton

Sandrine Holt

Matty Webber

Meredith Eaton

Wilt Bozer

Justin Hires

Guest Star

Tobias Jelenek

Guest Star

Thomas Kopache

Guest Star

Amy Acker

Billy Colton

Lance Gross

Guest Star

Sonia Rockwell

Nikki Carpenter

Tracy Spiridakos

Guest Star

Oliver Cooper

Guest Star

Cheyenne Haynes

Guest Star

Michael Michele

Guest Star

Siobhan Fallon Hogan

Chin Ho Kelly

Daniel Dae Kim

Guest Star

John Heard

Guest Star

Aina Dumlao

Guest Star

Nicholas X. Parsons

Guest Star

Joe Ando-Hirsh

Guest Star

Anthony DiRocco

Desiree "Desi" Nguyen

Levy Tran

John Kendrick

Vinnie Jones

Guest Star

Frank Whaley

Guest Star

Svetlana Efremova

Guest Star

Kasha Kropinski

Kono Kalakaua

Grace Park

Frankie

Aly Michalka

The Client/Daniel Holt

William Mapother

Guest Star

David Dastmalchian

Charlie Robinson

Emerson Brooks

Guest Star

Keith Jardine

Guest Star

Garrett Kruithof

Guest Star

Elya Baskin

Guest Star

Sir Brodie

Guest Star

Amiah Miller

Guest Star

Walter Tabayoyong

Guest Star

Olex Krupka

Guest Star

Rachel Kylian

Guest Star

Christian Chamberlin

Guest Star

Sean Michael Weber

Guest Star

Richard Thomas Koghberger

Guest Star

Christopher Heyerdahl

Fake Dr. Zito

Mark A. Sheppard

Richard Sang

Francois Chau

Joshua Abdal Khalid

Assaf Cohen

Guest Star

Jocko Sims

Russ Taylor

Henry Ian Cusick

Guest Star

Gary Weeks

Kamekona

Taylor Wily

Guest Star

Zulay Henao

Guest Star

Raoul Trujillo

Guest Star

Aimee Carrero

Guest Star

Luke Arnold

Guest Star

Sheryl Lee Ralph

Guest Star

Alicia Coppola

Vincent the Director

Cory Scott Allen

Tiffany

India Batson

Guest Star

Danielle Lyn

Guest Star

Jabari Marshall

Guest Star

Christain Chamberlain

Guest Star

Michael Tow

Guest Star

Deborah Mace

Guest Star

Jeremy London

Guest Star

Yorgo Constantine

Guest Star

Jarreth Merz

Guest Star

Al Vincente

Guest Star

Darla Delgado

Guest Star

Lyman Chen

Jill Morgan

Kate Bond

Smitty

Bill Posley

Guest Star

Keith Meriweather

Guest Star

Javicia Leslie

Guest Star

Sophie Edwards

Guest Star

India Batson

Guest Star

Andrew Ayala

Doorman

Alessandro Folchitto

Guest Star

G-Rod

Guest Star

Cindy L. Jefferson

Guest Star

Jermaine Rivers

Guest Star

Lobo Sebastian

Guest Star

Sammi Rotibi

Ed Morris

Michael Harding

Guest Star

Brandon O'Dell

Samantha Cage

Isabel Lucas

Guest Star

Benjamin Taylor

Guest Star

Sam Medina

Guest Star

Joselin Reyes

Farhad

Farshad Farahat

Guest Star

Eyas Younis

Guest Star

Matt Mercurio

Guest Star

Hunter Burke

Guest Star

Alban Merdani

Guest Star

Joshua Chang

Guest Star

Pat Dortch

Guest Star

Selena Anduze

Guest Star

Alessandro Folchitto

Guest Star

Hans Marrero

Guest Star

Alan T. Coleman

Guest Star

Chas Harvey

Cindy Morris

Susan Macke Miller

Guest Star

Olivia Welch

Guest Star

Christine Horn

Guest Star

Bob Bost

Guest Star

Niko Nicotera

Guest Star

Michael Graziadei

Guest Star

Tze Yep

Lead Tech/Dying

Elizabeth Tavares

Oversight

Tate Donovan

Guest Star

Danielle Deadwyler

Guest Star

Bianca Malinowski

Guest Star

Philip Fornah

Guest Star

Tony Demil

Guest Star

Jonathan Ralph Fritschi

Reporter

Amor Owens

Guest Star

Angela M. Davis

Guest Star

Jessica Roth

Guest Star

Cedric Greenway

Guest Star

Josefina Boneo

Guest Star

Kirill Sheynerman

Guard

Hamid-Reza Benjamin Thompson

Dr. Zito

Troy Rudeseal

FEMA Director Sam Hopkins

C.S. Lee

Guest Star

Dheeaba Donghrer

Guest Star

Billy Blair

Guest Star

Zoe Smith

Guest Star

Ryan Lewis

Guest Star

Gregg Christie

Guest Star

Kenneth Israel

Co-Pilot

Michael E. Sanders

Guest Star

Andrew Yun

Sergei / Russian Guard #2 / Silver Wall Security Guard

Andre Pushkin

Guest Star

Kent De Mond

Guest Star

Blake Burgess

Brett

Lycan Scott

EMT

Adam Roby Southard

Guest Star

John Atwood

Guest Star

Josh Ventura

Robot (voice)

Nicholas Guest

Guest Star

Bill Stinchcomb

Kalei

Rome Flynn

Guest Star

Michael E. Sanders

Guest Star

Kaleka

Nurse

Amy Hui

Guard

Jeff Wolfe

Christine

Candace Moon

Guest Star

Tim Sitarz

Guest Star

Preston James Hillier

Guest Star

Serdar Kalsin

Elwood

William Baldwin

Lead Tech DXS

Craig Newman

Guest Star

Tony Mcfarr

Guest

Ian Gregg

Guest Star

Carlos Guerrero

Amelia

Sara Naby Kim

Armed Guard

Don DiPetta

Guest Star

Inge Uys

Guest Star

Alan Richmond

Scarlett

Amber Skye Noyes

Samir

Nik Kash

Guest Star

Robin F. Baker

Guest Star

Jorge Longoria

Emily Espinoza

Camille Chen

Parker

Alexandra Grey

Mayumi

Cindy Chu

Nasha

Sibongile Mlambo

MacGyver

Richard Dean Anderson

Andy Colson

Dana Elcar

Dr. Burke

Michael C. Gwynne

Gen. Relkwin

Michael Fairman

Reggie

Shavar Ross

Barbara Spencer

Darlanne Fluegel*

Dr. Sidney Marlowe

Olaf Pooley

Major Dennis

Charles Lanyer

Technician #1

Charles Bouvier

Technician #3

Larry Watson

Pilot

Richard Partlow

Director

Joe Dante

Director

Lee Rose

Director

Matt Earl Beesley

Director

Duane Clark

Director

Jerrold Freedman

Director

James Wan

Director

Gabriel Beristain

Director

Janice Cooke

Director

Tawnia McKiernan

Director

Sylvain White

Director

Eagle Egilsson

Director

Antonio Negret

Director

Alan Smithee

Director

Liz Allen

Director

Stephen Herek

Director

Jerry Levine

Director

Bobby Roth