Angus "Mac" MacGyver
Lucas Till
Jack Dalton
George Eads
Riley Davis
Tristin Mays
Patricia Thornton
Sandrine Holt
Matty Webber
Meredith Eaton
Wilt Bozer
Justin Hires
Guest Star
Tobias Jelenek
Guest Star
Thomas Kopache
Guest Star
Amy Acker
Billy Colton
Lance Gross
Guest Star
Sonia Rockwell
Nikki Carpenter
Tracy Spiridakos
Guest Star
Oliver Cooper
Guest Star
Cheyenne Haynes
Guest Star
Michael Michele
Guest Star
Siobhan Fallon Hogan
Chin Ho Kelly
Daniel Dae Kim
Guest Star
John Heard
Guest Star
Aina Dumlao
Guest Star
Nicholas X. Parsons
Guest Star
Joe Ando-Hirsh
Guest Star
Anthony DiRocco
Desiree "Desi" Nguyen
Levy Tran
John Kendrick
Vinnie Jones
Guest Star
Frank Whaley
Guest Star
Svetlana Efremova
Guest Star
Kasha Kropinski
Kono Kalakaua
Grace Park
Frankie
Aly Michalka
The Client/Daniel Holt
William Mapother
Guest Star
David Dastmalchian
Charlie Robinson
Emerson Brooks
Guest Star
Keith Jardine
Guest Star
Garrett Kruithof
Guest Star
Elya Baskin
Guest Star
Sir Brodie
Guest Star
Amiah Miller
Guest Star
Walter Tabayoyong
Guest Star
Olex Krupka
Guest Star
Rachel Kylian
Guest Star
Christian Chamberlin
Guest Star
Sean Michael Weber
Guest Star
Richard Thomas Koghberger
Guest Star
Christopher Heyerdahl
Fake Dr. Zito
Mark A. Sheppard
Richard Sang
Francois Chau
Joshua Abdal Khalid
Assaf Cohen
Guest Star
Jocko Sims
Russ Taylor
Henry Ian Cusick
Guest Star
Gary Weeks
Kamekona
Taylor Wily
Guest Star
Zulay Henao
Guest Star
Raoul Trujillo
Guest Star
Aimee Carrero
Guest Star
Luke Arnold
Guest Star
Sheryl Lee Ralph
Guest Star
Alicia Coppola
Vincent the Director
Cory Scott Allen
Tiffany
India Batson
Guest Star
Danielle Lyn
Guest Star
Jabari Marshall
Guest Star
Christain Chamberlain
Guest Star
Michael Tow
Guest Star
Deborah Mace
Guest Star
Jeremy London
Guest Star
Yorgo Constantine
Guest Star
Jarreth Merz
Guest Star
Al Vincente
Guest Star
Darla Delgado
Guest Star
Lyman Chen
Jill Morgan
Kate Bond
Smitty
Bill Posley
Guest Star
Keith Meriweather
Guest Star
Javicia Leslie
Guest Star
Sophie Edwards
Guest Star
India Batson
Guest Star
Andrew Ayala
Doorman
Alessandro Folchitto
Guest Star
G-Rod
Guest Star
Cindy L. Jefferson
Guest Star
Jermaine Rivers
Guest Star
Lobo Sebastian
Guest Star
Sammi Rotibi
Ed Morris
Michael Harding
Guest Star
Brandon O'Dell
Samantha Cage
Isabel Lucas
Guest Star
Benjamin Taylor
Guest Star
Sam Medina
Guest Star
Joselin Reyes
Farhad
Farshad Farahat
Guest Star
Eyas Younis
Guest Star
Matt Mercurio
Guest Star
Hunter Burke
Guest Star
Alban Merdani
Guest Star
Joshua Chang
Guest Star
Pat Dortch
Guest Star
Selena Anduze
Guest Star
Alessandro Folchitto
Guest Star
Hans Marrero
Guest Star
Alan T. Coleman
Guest Star
Chas Harvey
Cindy Morris
Susan Macke Miller
Guest Star
Olivia Welch
Guest Star
Christine Horn
Guest Star
Bob Bost
Guest Star
Niko Nicotera
Guest Star
Michael Graziadei
Guest Star
Tze Yep
Lead Tech/Dying
Elizabeth Tavares
Oversight
Tate Donovan
Guest Star
Danielle Deadwyler
Guest Star
Bianca Malinowski
Guest Star
Philip Fornah
Guest Star
Tony Demil
Guest Star
Jonathan Ralph Fritschi
Reporter
Amor Owens
Guest Star
Angela M. Davis
Guest Star
Jessica Roth
Guest Star
Cedric Greenway
Guest Star
Josefina Boneo
Guest Star
Kirill Sheynerman
Guard
Hamid-Reza Benjamin Thompson
Dr. Zito
Troy Rudeseal
FEMA Director Sam Hopkins
C.S. Lee
Guest Star
Dheeaba Donghrer
Guest Star
Billy Blair
Guest Star
Zoe Smith
Guest Star
Ryan Lewis
Guest Star
Gregg Christie
Guest Star
Kenneth Israel
Co-Pilot
Michael E. Sanders
Guest Star
Andrew Yun
Sergei / Russian Guard #2 / Silver Wall Security Guard
Andre Pushkin
Guest Star
Kent De Mond
Guest Star
Blake Burgess
Brett
Lycan Scott
EMT
Adam Roby Southard
Guest Star
John Atwood
Guest Star
Josh Ventura
Robot (voice)
Nicholas Guest
Guest Star
Bill Stinchcomb
Kalei
Rome Flynn
Guest Star
Michael E. Sanders
Guest Star
Kaleka
Nurse
Amy Hui
Guard
Jeff Wolfe
Christine
Candace Moon
Guest Star
Tim Sitarz
Guest Star
Preston James Hillier
Guest Star
Serdar Kalsin
Elwood
William Baldwin
Lead Tech DXS
Craig Newman
Guest Star
Tony Mcfarr
Guest
Ian Gregg
Guest Star
Carlos Guerrero
Amelia
Sara Naby Kim
Armed Guard
Don DiPetta
Guest Star
Inge Uys
Guest Star
Alan Richmond
Scarlett
Amber Skye Noyes
Samir
Nik Kash
Guest Star
Robin F. Baker
Guest Star
Jorge Longoria
Emily Espinoza
Camille Chen
Parker
Alexandra Grey
Mayumi
Cindy Chu
Nasha
Sibongile Mlambo
MacGyver
Richard Dean Anderson
Andy Colson
Dana Elcar
Dr. Burke
Michael C. Gwynne
Gen. Relkwin
Michael Fairman
Reggie
Shavar Ross
Barbara Spencer
Darlanne Fluegel*
Dr. Sidney Marlowe
Olaf Pooley
Major Dennis
Charles Lanyer
Technician #1
Charles Bouvier
Technician #3
Larry Watson
Pilot
Richard Partlow
Director
Joe Dante
Director
Lee Rose
Director
Matt Earl Beesley
Director
Duane Clark
Director
Jerrold Freedman
Director
James Wan
Director
Gabriel Beristain
Director
Janice Cooke
Director
Tawnia McKiernan
Director
Sylvain White
Director
Eagle Egilsson
Director
Antonio Negret
Director
Alan Smithee
Director
Liz Allen
Director
Stephen Herek
Director
Jerry Levine
Director
Bobby Roth