Spawn
Keith David
Wanda Blake
Dominique Jennings
Nicholas Cogliostro (voice)
Richard Dysart
Terry Fitzgerald/Bobby
Victor Love
Tony Twist/Sam Burke
James Keane
Clown (voice)
Michael Nicolosi
Jason Wynn (voice)
John Rafter Lee
Twitch Williams (voice)
Michael McShane
Senator Scott McMillan/Billy Kincaid
Ronny Cox
—
Todd McFarlane
Kath Soucie*
Cyan
Kath Soucie
Terry Fitzgerald (voice)
Michael Beach
—
Jennifer Jason Leigh