Secret Service Man #1 / Lieutenant (voice)
Rob Letterman
Susan Murphy / Ginormica (voice)
Reese Witherspoon
Commander / Advisor Smith (voice)
Bo Dietl
Dr. Cockroach Ph.D.
Hugh Laurie
B.O.B. (voice)
Seth Rogen
The Missing Link
Will Arnett
Gallaxhar (voice)
Rainn Wilson
General W.R. Monger
Kiefer Sutherland
Derek Dietl (voice)
Paul Rudd
Gallaxhar
Rainn Wilson
The President of the United States
Stephen Colbert
Wendy Murphy (voice)
Julie White
Carl Murphy (voice)
Jeffrey Tambor
Computer (voice)
Amy Poehler
News Reporter (voice)
Ed Helms
Katie (voice)
Renée Zellweger
Insectosaurus
Jimmy Kimmel
Private Bullhorn / Helicopter Pilot / Advisor Ortega (voice)
Sean Bishop
Bridesmaid Candy (voice)
Lisa Stewart
Louise Bourgoin
Stéphane Freiss
Wilson (voice)
Tom McGrath
Advisor Cole / Army Commander Jones (voice)
Chris Miller
Julien Doré
Advisor Wedgie (voice)
Mike Mitchell
Dorothée Pousséo
Gilbert Lévy
Technician Jerry (voice)
Kent Osborne
Nessym Guetat
Panicked Guest / Female Advisor #2 / Mrs. Ronson / Advisor O
Latifa Ouaou
Soldier #4 / Pilot / Soldier #3
Geoffrey Pomeroy
Soldier #1 / Advisor Jackson (voice)
David P. Smith
Advisor Hawk / Advisor Dither / Minister
Conrad Vernon
Stine Stengade
Diana Amft
Cuthbert (voice)
John Krasinski
Oliver Kalkofe
Technician Bee (voice)
Stephen Kearin
Erich Räuker
Ralph Moeller
Tobias Meister
Frank Schaff
Peter Flechtner
Sebastian Höffner
Monica Bielenstein
Rüdiger Evers
Ranja Bonalana
Vera Teltz
Olaf Reichmann
Werner Ziebig