B.O.B.

Oliver Kalkofe

Secret Service Man #1 / Lieutenant (voice)

Rob Letterman

Susan Murphy / Ginormica

Reese Witherspoon

Susan Murphy / Ginormica

Han Ye-seul

B.O.B. (voice)

Seth Rogen

Commander / Advisor Smith (voice)

Bo Dietl

Carl Murphy

Rüdiger Evers

Dr. Cockroach Ph.D. (voice)

Hugh Laurie

Computer

Ranja Bonalana

The Missing Link

Will Arnett

Gallaxhar (voice)

Rainn Wilson

Cuthbert

Olaf Reichmann

General W.R. Monger

Kiefer Sutherland

Derek

Sebastian Höffner

Derek

Paul Rudd

Dr. Cockroach

Erich Räuker

The President of the United States

Stephen Colbert

Wendy Murphy (voice)

Julie White

Carl Murphy (voice)

Jeffrey Tambor

Computer (voice)

Amy Poehler

News Reporter (voice)

Ed Helms

Katie (voice)

Renée Zellweger

Private Bullhorn / Helicopter Pilot / Advisor Ortega (voice)

Sean Bishop

Insectosaurus

Jimmy Kimmel

Bridesmaid Candy (voice)

Lisa Stewart

Wilson (voice)

Tom McGrath

Louise Bourgoin

Advisor Cole / Army Commander Jones (voice)

Chris Miller

Stéphane Freiss

Advisor Wedgie (voice)

Mike Mitchell

Julien Doré

Technician Jerry (voice)

Kent Osborne

Dorothée Pousséo

Gilbert Lévy

Advisor Ouaou / Mrs. Ronson / Female Advisor #2 / Panicked Guest (voice)

Latifa Ouaou

Soldier #4 / Pilot / Soldier #3 / News Technician (voice)

Geoffrey Pomeroy

Nessym Guetat

Soldier #1 / Advisor Jackson (voice)

David P. Smith

Advisor Hawk / Advisor Dither / Minister / Secret Service Man #2 / Mama Dietl (voice)

Conrad Vernon

Cuthbert (voice)

John Krasinski

Stine Stengade

Diana Amft

Technician Bee (voice)

Stephen Kearin

Ralf Moeller

Tobias Meister

Frank Schaff

Peter Flechtner

Monica Bielenstein

Vera Teltz

Werner Ziebig