Fred/Scooby

Frank Welker

Shaggy Rogers (voice)

Matthew Lillard

Velma Dinkley (voice)

Mindy Cohn

Daphne

Grey DeLisle

Rick Yantz/Announcer/Hospital PA

Dave "Gruber" Allen

Kriegstaffebot (Voice) / Gene Shepherd (voice) / Junk (voice)

Dee Bradley Baker

Ernesto/Todd

Carlos Alazraqui

Luna

Kimberly Brooks

Eager Clerk/Clerk's Pet

Eric Bauza

Dreamweaver (voice) / Curator Vronsky (voice) / Krod (voice)

Troy Baker

Mary-Ann Geerdon/Tiffany

Isabella Acres

Captain Caveman

Jim Cummings

Older Danny Darrow

Dwight Schultz

Mr. E (voice) / Mr. E (voice) / Mr. E

Lewis Black

Sheila Altoonian

Beverly D'Angelo

Dead Justice

Powers Boothe

Bud Coleman

David Faustino

Gary (voice) / Gary / Referee #2 (voice)

Tony Cervone

Arthur Baywosenthal

Zach Callison

Angel Dynamite (voice) / Cassidy Williams (voice) / Cassidy Williams

Vivica A. Fox

Judy Reeves (voice) / Amy (voice)

Tia Carrere

Marcie 'Hot Dog Water' Fleach (voice) / Marcy 'Hot Dog Water' Fleach (voice) / Hot Dog Water (voice)

Linda Cardellini

Sheriff Bronson Stone (voice) / Sheriff Stone (voice)

Patrick Warburton

H.P. Hatecraft

Jeffrey Combs

Charles "Cachinga" Wheatlesby

Greg Ellis

Hugh Dederdee

Joe Holt

Daniel Prezette/Frantzee Pantz/Gus Boggs

Quinton Flynn

Younger Danny Darrow

Will Shadley

Mayor Janet Nettles (voice) / Principal Quinlan (voice)

Kate Higgins

Garden Manager/Maitre D'

Kevin Dunn

Mayor Fred Jones Sr. (voice) / Mayor Fred Jones Sr. / Motorcycle Cop (voice)

Gary Cole

Angie Dinkley (voice) / Mrs. Dinkley (voice)

Frances Conroy

Lady Marmalade

Cree Summer

Weena/Waitress

April Winchell

Thorn

Jennifer Hale

Ed Machine/Announcer/Creepy Voice

Richard McGonagle

Ruby Stone

Florence Henderson

Professor Pericles (voice)

Udo Kier

Maxwell/Spanker Chief/Shadowy Ore

Chris Hardwick

Chen/Red Wizard

James Hong

Marion Spartan

Julie Bowen

Young Man/Ben

David Markus

Funky Phantom/Chairman

Tom Kenny

Harry Schnesle-Boysen

David Juskow

Grandma Moonbeam

Marion Ross

Dr. Rick Spartan

James Patrick Stuart

Gunther Gator

Billy West

Vincent Van Ghoul (voice)

Maurice LaMarche

Jason

Daryl Sabara

Skipper's Brother

Daran Norris

Aphrodite/Amanda Smyth

Tricia Helfer

Skipper Shelton (voice)

John O'Hurley

Mai Le

Stephanie Sheh

Himself

Harlan Ellison

Winslow Fleach

Rob Paulsen

Colton Rogers

Casey Kasem

Mr. Wang/White Wizard

George Takei

Demon Dog

Fred Tatasciore

Peter Trickell

George Segal

Grady Gator/Delivery Guy

John DiMaggio

George Avocados (voice) / George Avocados / Rung Ladderton

James Arnold Taylor

Gill Littlefoot

Jeffrey Tambor

Kelsepsian/Jingle Singer/Hairy Sasquach

Paul Rugg

Gabtraf

Phil Idrissi

Nan Blake (voice)

Kath Soucie

Professor Emmanuel Raffalo/Tourist

Jeff Bennett

Dean Fenk

Mindy Sterling

Dr. Cavanaugh

Gary Anthony Williams

Odnarb

Ben McKenzie

Lord Infernicus/Boo

Rick Wasserman

Jason's Mom

Jessica Walter

Ben/Rhino/Cook/Howard E. Robertson

Crispin Freeman

Brenda

Beth Tapper

Lord Barry

Lloyd Sherr

Dad

David Kaye

Alice May

Hynden Walch

Dusk

Jane Wiedlin

Hulking Red/Urchin Captain/Buddy

Kevin M. Richardson

Queen Amanda

Audrey Wasilewski

Ethan (voice) / Farmer (voice)

Mitch Watson

Judy Reeves/Regina Wentworth

Kari Wahlgren

Ricky Owens

Scott Menville

Brad Chiles (voice)

Tim Matheson

Brad Chiles

Nolan North

Kath Soucie*

Arturo Mercado

Domitilla D'Amico

Director

Curt Geda

Director

Victor Cook

Director

Lauren Montgomery