Adult Swim describes "The Heart, She Holler" as a "live-action soap opera about folk who ain't never used soap or seen an opera." Specifically, it's set in Heartshe Holler, a town with such a long history of inbreeding that its residents aren't, shall we say, normal. When Hurlan Heartshe -- the secret, long-hidden son of the Heartshe dynasty -- returns to run the town, a conflict ensues with his sisters, Hurshe and Hambrosia, who are trying to take over the town themselves.