In this reimagining of the classic Dracula story, the world is dominated by vampires, requiring humans to work together to survive. The series centers on Vanessa Helsing, daughter of famed vampire hunter Abraham Van Helsing, who wakes up after a five-year coma to discover a vampire-controlled world. She soon learns that she possesses a unique blood composition that makes her immune to vampires and able to turn the creatures into humans. That power puts humanity's last hope to return the world to how it once was before the vampires took over in Vanessa's hands.