Frank Reagan

Tom Selleck

Henry Reagan

Len Cariou

Danny Reagan

Donnie Wahlberg

Erin Reagan

Bridget Moynahan

Jamie Reagan

Will Estes

Detective Jackie Curatola

Jennifer Esposito

Linda Reagan

Amy Carlson

Garrett Moore

Gregory Jbara

Nicky Reagan-Boyle / Nicky

Sami Gayle

Eddie Stone

Dash Mihok

Sgt. Anthony Renzulli

Nick Turturro

Abigail Baker

Abigail Hawk

Curtis Swint

Mark Moses

Lacey

Charlotte Sullivan

Detective Wolf Landsman

Luke Kirby

Dr. Grace Meherin

Annabella Sciorra

Sean Reagan

Andrew Terraciano

Rachel Manning

Adrienne Warren

Richard Rourke

Eric Mabius

Detective Maria Baez

Marisa Ramirez

Letitia Williams

Victoria Cartagena

Zachary Danhart

Brian Avers

Jack Reagan

Tony Terraciano

Tommy Banks

Dana Ashbrook

Detective Kate Lansing

Megan Ketch

Garrett Moore

Robert Clohessy

Councilman Tommy Mancini

Richard Burgi

Vance Bradley

Reg Rogers

Whitney Robshaw

Sarah Wynter

Bobby

Jordan Gelber

Detective Freehill

Danny Mastrogiorgio

Vinny Cruz

Sebastian Sozzi

Angela Ferrera

Lili Mirojnick

Jared Mehra

Bhavesh Patel

Holly / Rhonda Lynne Watson

Savannah Wise

Robert Carter

Brian J. Smith

Richie Tomlin

Vincent Pastore

Jordan Silva

Justin Martin

Ken

Travis Schuldt

Dr. Ed Greenfield

Jon Patrick Walker

Isabelle Nassar

Sheetal Sheth

John 'Jack' Boyle

Peter Hermann

Kevin Carr

Chris Tardio

Santana

Kamar de los Reyes

Candice McElroy

Megan Boone

Eddie Janko / Eddie Reagan

Vanessa Ray

CIA Anne Reynolds

Michelle Hurd

Jana Garza

Audrey Esparza

Vince D'Amato

Peter Onorati

Pete Seabrook

Brian Kerwin

Lieutenant Perez

Paul Calderon

Sam Croft

Teddy Sears

Patrice

Tawny Cypress

Reverend Darnell Potter

Ato Essandoh

Grace Newhouse

Joanna Gleason

Officer Blake

Corbin Bleu

Captain Derek Elwood

Nestor Serrano

Detective Sidney Jeffries

Owiso Odera

Doc

David Wilson Barnes

Officer Peter Grasso

Zack Robidas

Chief of Detectives Ed Hines

John Rue

Prof. Brian Devlin

Malcolm Gets

Dino Arbogast

John Ventimiglia

Mayor Frank Russo / Robert Levitt

Bruce Altman

Leaf Memphis

Neal Huff

Ricky

Rick Gonzalez

Sheri Dean

Samantha Buck

Jacob

Stephen Kunken

Mons. Walter Donahue

Kevin O'Rourke

Anthony Abetemarco

Steve Schirripa

Jimmy Deleo

McCaleb Burnett

Johnny Evans

Shane McRae

Lawrence Skolnick

Matthew Rauch

ADA Saul Ward

Thom Barry

Dana

Laura Breckenridge

Abdul Sayid

Louis Ozawa Changchien

Bryce Helfond / Chief of Intel / Inter Chief

Victor Slezak

Joyce Powers

Carolyn McCormick

Raul

Juan Carlos Hernández

Dave Greenwald

Jason Kravits

Mr. Wojcik

Michael Kostroff

ESU Captain

David Fonteno

Superintendant

Anthony J. Gallo

Asher Lefko

Darren Goldstein

Joe Ferraro

Lenny Platt

Nona Palmeira

Ana Nogueira

Tyler Green

Daniel London

Amanda Harris

Amy Morton

Rivka Morganthal

Melissa Errico

Guest Star

Rosemary DeAngelis

Guest Star

Nasser Faris

Sally Burton

Geneva Carr

Guest Star

Lucas Papaelias

Guest Star

Judith Delgado

Benjamin Walker

Michael Madsen

Guest Star

Eden Marryshow

Guest Star

Keith Eric Chappelle

Guest Star

Tony Plana

Doctor

Sally Wheeler

Guest Star

Beth Chamberlin