Lillian

Maya Rudolph

Annie

Kristen Wiig

Rita

Wendi McLendon-Covey

Becca

Ellie Kemper

Helen

Rose Byrne

Don Cholodecki

Michael Hitchcock

Officer Rhodes

Chris O'Dowd

Kahlua

Kali Hawk

Megan

Melissa McCarthy

Oscar the Security Guard

Joseph A. Nuñez

Brynn

Rebel Wilson

Gil

Matt Lucas

Kevin

Greg Tuculescu

Ted

Jon Hamm

Annie's Mom

Jill Clayburgh

Annie's Mistaken Husband

Steve Bannos

Annie's Mistaken Fella

Hugh Dane

Lillian's Dad

Franklyn Ajaye

Dougie

Tim Heidecker

Lillian's Mom

Lynne Marie Stewart

Helen's Husband

Andy Buckley

Helen's Stepdaughter

Molly Buffington

Rodney

Terry Crews

Helen's Stepson

Matt Bennett

Whitney

Jessica St. Clair

Helen's Tennis Partner

Nancy Carell

Annie's Tennis Partner

Melanie Hutsell

Flight Attendant Claire

Dana Powell

Flight Attendant Steve

Mitch Silpa

Nervous Woman on Plane

Annie Mumolo

Air Marshall Jon

Ben Falcone

Carnie Wilson

Carnie Wilson

Flight Attendant in Coach

Angelina Acedo

Chynna Phillips

Chynna Phillips

13-Year-Old Girl in Jewelry Store

Mia Rose Frampton

Wendy Wilson

Wendy Wilson

13-Year-Old Girl's Father

Joel Madison

Butler

R.F. Daley

Horseman

Jordan Black

Jewelry Store Couple

Tom Yi

Doorman at Shower

David Hoffman

Jewelry Store Couple

Elaine Kao

Minister

Jimmy Brogan

Pete

Brian Petsos

Bill Cozbi

Richard Riehle

Girl at Shower

Jillian Bell

Girl at Shower

Ariane Price

Shower Waiter

Frederik Hamel

Greg Worswick*

Joanna Theobalds