Lillian

Maya Rudolph

Annie

Kristen Wiig

Rita

Wendi McLendon-Covey

Becca

Ellie Kemper

Helen

Rose Byrne

Rhodes

Chris O'Dowd

Don Cholodecki

Michael Hitchcock

Megan

Melissa McCarthy

Kahlua

Kali Hawk

Oscar the Security Guard

Joseph A. Nuñez

Brynn

Rebel Wilson

Annie's Mom

Jill Clayburgh

Gil

Matt Lucas

Ted

Jon Hamm

Kevin

Greg Tuculescu

Annie's Mistaken Husband

Steve Bannos

Annie's Mistaken Fella

Hugh Dane

Lillian's Dad

Franklyn Ajaye

Boot Camp Instructor

Terry Crews

Dougie

Tim Heidecker

Jewelry Store Couple

Tom Yi

Jewelry Store Couple

Elaine Kao

Lillian's Mom

Lynne Marie Stewart

Carnie Wilson

Carnie Wilson

Helen's Husband

Andy Buckley

Girl at Shower

Jillian Bell

Helen's Stepdaughter

Molly Buffington

Nervous Woman on Plane

Annie Mumolo

Air Marshall Jon

Ben Falcone

Helen's Stepson

Matt Bennett

Whitney

Jessica St. Clair

Helen's Tennis Partner

Nancy Carell

Annie's Tennis Partner

Melanie Hutsell

Flight Attendant Claire

Dana Powell

Flight Attendant Steve

Mitch Silpa

Flight Attendant in Coach

Angelina Acedo

Chynna Phillips

Chynna Phillips

13-Year-Old Girl in Jewelry Store

Mia Rose Frampton

Wendy Wilson

Wendy Wilson

13-Year-Old Girl's Father

Joel Madison

Churra Chi Waiter

Eloy Casados

Butler

R.F. Daley

Horseman

Jordan Black

Doorman at Shower

David Hoffman

Minister

Jimmy Brogan

Pete

Brian Petsos

Flight Attendant in Coach

Angelica Acedo

Bill Cozbi

Richard Riehle

Girl at Shower

Ariane Price

Shower Waiter

Frederik Hamel

Valet (uncredited)

Greg Worswick

Joanna Theobalds

Tyler (as Blake Garrett)

Blake Garrett Rosenthal

Wedding Guest (uncredited)

Paul Feig

Old Woman in Car (uncredited)

Pat Carroll

Hostess (uncredited)

Suzanne LaChasse

Obnoxious Ice Skater (uncredited)

Owen Daniels