Lunella Lafayette / Moon Girl (voice)
Diamond White
Devil Dinosaur (voice)
Fred Tatasciore
Mimi Lafayette (voice)
Alfre Woodard
Adria Lafayette (voice)
Sasheer Zamata
Casey Calderon (voice)
Libe Barer
James Lafayette Jr. (voice)
Jermaine Fowler
Pops
Gary Anthony Williams
The Beyonder (voice) / Foster (voice)
Laurence Fishburne
Eduardo (voice)
Michael Cimino
Alfretta (voice) / Staten Island Passenger (voice) / Dani (voice)
Kimberly Brooks
Brooklyn (voice)
Indya Moore
Anand (voice)
Utkarsh Ambudkar
Jonathan Powers / Jester (voice) / Alien Gang Soldier 1 (voice)
Kalen Aris Whitfield
Maria Hill (voice)
Cobie Smulders
Geri (voice)
Tajinae Turner
Clueless Girl (voice) / Chloé (voice) / Brooklyn's Mom (voice)
Alanna Ubach
Ahmed (voice)
Omid Abtahi
LOS-307 (voice)
Asia Kate Dillon
Principal Nelson (voice)
Craig Robinson
Tai (voice)
Ian Alexander