Roger Waddell

Jon Heder

Dr. P

Billy Bob Thornton

Amanda

Jacinda Barrett

Lesher

Michael Clarke Duncan

Becky

Sarah Silverman

Diego

Horatio Sanz

Sergeant Moorehead

Luis Guzmán

Ian

David Cross

Walsh

Matt Walsh

Lawrence

Omar Dorsey

Eli

Todd Louiso

Shanice (uncredited)

Nicole Randall Johnson

Lonnie Ratcliff

Ben Stiller

Bee Bee

DeRay Davis

Lois

Joanne Baron

Benny

Teddy Coluca

Zack

Dan Fogler

Little Pete

Paul Scheer

Ernie

Jon Glaser

Classmate

Leonard Earl Howze

Mrs. Washington

Marcella Lowery

Dr. P's Student

Jim Parsons

Dr. P's Student

Aziz Ansari

Dr. P's Student

Remy K. Selma

Dr. P's Student

Andrew Daly

Dr. P's Student

Matt Besser

Classmate

Bob Stephenson

Dr. P's Student

Joe Nunez

Dr. P's Student

Jack Kehler

Bus Guy No.1

Noel Gugliemi

Dr. P's Student

Armen Weitzman

Bus Guy No.2

Daniel Venegas

Eli's Wife

Jessica Stroup

Flight Attendant

Lizz Carter

Male Flight Attendant

Steve Monroe

Mindy

Khadijah

Margaret (uncredited)

Malika

Ruth

Natalie Core

Woman (uncredited)

Bernadette Birkett

Waitress (uncredited)

Che Landon

Flight Attendant

Tarina Pouncy

Tennis Player

Kimberly Evan