Theodore Templeton
Alec Baldwin
Tim Templeton
James Marsden
Carol Templeton(voice)
Eva Longoria
Tina Templeton/Boss Baby
Amy Sedaris
Dr. Armstrong
Jeff Goldblum
Tabitha
Ariana Greenblatt
Ted Templeton(voice)
Jimmy Kimmel
Janice Templeton
Lisa Kudrow
Wizzie (voice)
James McGrath
Nathan / Lead Baby Ninja (voice)
Raphael Alejandro
Meghan (voice)
Serenity Reign Brown
Jimbo (voice)
David Soren
Box Kid(voice)
Reyn Doi
Gracen Newton
The Triplets (voice)
Nicholas Gist
Creepy Girl
Molly K. Gray
Tim Templeton(voice)
Buddy Vedder
Story Bear (Connie) (voice)
James Ryan
Al Saif Alshad(voice)
Al Saif Alshad
Movie Patron (voice)
David P. Smith
Little Bo Peep Baby (voice)
Nova Reed
Creepy Girl (voice)
Molly K. Gray
'No' Girl (voice)
Ashlyn Lundahl
Glue Baby (voice)
Dave Needham
Dr. Tiffany Hamilton (voice)
Tom McGrath
Time Out Kid (voice)
Collin Erker
Baby Bouncer (voice)
Walt Dohrn
Acorn Center Computer (voice)
April Lawrence
Young Tim Voice-Over (voice)
Miles Bakshi
Pageant Mom 1 (voice)
Kristin Lowe
Pageant Mom 2 (voice)
Marjorie Cohn
Dreidel Kid (voice)
Connor Albrecht