Jimmy Neutron (voice)

Debi Derryberry

Goddard

Frank Welker

Cindy Vortex (voice) / Cindy Vortex / Tina Sue (voice)

Carolyn Lawrence

Sheen Estevez (voice)

Jeffrey Garcia

Carlton Ulysses Wheezer

Rob Paulsen

Nick Dean (voice) / Britney (voice) / Nick Dean

Candi Milo

Judy Neutron (voice) / Judy Neutron / Woman (voice)

Megan Cavanagh

Hugh Neutron (voice) / Hugh Neutron / General

Mark DeCarlo

Libby Folfax (voice) / Libby Folfax / Chuck (voice)

Crystal Scales

Ms. Fowl (voice) / Ms. Fowl / Lady (voice)

Andrea Martin

Sam Melnick (voice) / Corky Shimatzu / Larry Llama (voice)

Billy West

Bolbi (voice) / Bolbi / Pitz

Phil LaMarr

Ultra Lord (voice) / Popbot / Gortox

Jim Cummings

Nanobot #2 (voice) / Max / Wilderman

Tom Kenny

Travoltron / Barbarino (voice) / Newscaster

Jeff Bennett

Dr. Dark / Pizza Monster (voice) / Head Monk (voice)

Corey Burton

Zix / Ticket Taker (voice) / Tee

Maurice LaMarche

Betty Quinlan (voice)

Kath Soucie

Professor Calamitous (voice)

Tim Curry

Mombot (voice) / Elke (voice) / Sally (voice)

Grey DeLisle