Sarah/Beth/Alison/Cosima/Rachel/Helena

Tatiana Maslany

Felix 'Fee' Dawkins

Jordan Gavaris

Detective Arthur 'Art' Bell

Kevin Hanchard

Paul Dierden

Dylan Bruce

Siobhan 'Mrs. S' Sadler

Maria Doyle Kennedy

Mark/Ira

Ari Millen

Donald 'Donnie' Hendrix

Kristian Bruun

Delphine Cormier

Evelyne Brochu

Scott

Josh Vokey

Kira Manning

Skyler Wexler

Percival "P. T." Westmorland

Stephen McHattie

Professor Susan Duncan

Rosemary Dunsmore

Dr. Aldous Leekie

Matt Frewer

Nona Walker

Jayne Eastwood

Ferdinand Chevalier

James Frain

Dr. Virginia Coady

Kyra Harper

Detective Maddy Enger

Elyse Levesque

Leonard Sipp

Tom Cullen

Aynsley Norris

Natalie Lisinska

Victor 'Vic' Schmidt

Michael Mando

Gracie Johanssen

Zoé De Grand Maison

Simon Frontenac

Andrew Moodie

Young Helena

Habree Larratt

Young Rachel / Charlotte

Cynthia Galant

Chad Norris

Eric Johnson

The Messenger

Geza Kovacs

Mud

Jenessa Grant

Dr. Elizabeth Perkins

Sarah Orenstein

Reverend Mike / Reverend Mike (voice)

Ryan Blakely

Adele

Lauren Hammersley

Cooper

Stuart Hughes

Colin

Nicholas Rose

Ramone

Alex Ozerov

Gemma Hendrix

Millie Davis

Lieutenant Gavin Hardcastle

Ron Lea

Brie

Cara Ricketts

Hell Wizard

Calwyn Shurgold

Mr. Mitchell

Simi Liu

Detective Angela "Angie" Deangelis

Inga Cadranel

Oscar Hendrix

Drew Davis

Detective Martin "Marty" Duko

Gord Rand

Sarah Stubbs

Terra Hazelton

Evie Cho

Jessalyn Wanlim

Benjamin Kertland

Julian Richings

Dr. Alan Nealon

Tom McCamus

Cal Morrison

Michiel Huisman

Daniel Rosen

Matthew Bennett

Bonnie Johanssen

Kristin Booth

Ethan Duncan

Andrew Gillies

Shay Davydov

Ksenia Solo

Sister Irina

Eileen Sword

Tomas

Daniel Kash

Bobby

Diana Salvatore

Olivier Duval

David Richmond-Peck

Henrik "Hank" Johanssen

Peter Outerbridge

Marci Coates

Amanda Brugel

Kendall Malone

Alison Steadman

Roxie

Miranda Edwards

Dr. Ian Van Lier

Scott Wentworth

Aisha Yasin

Sirena Gulamgaus