Sarah/Beth

Tatiana Maslany

Paul

Dylan Bruce

Felix 'Fee' Dawkins

Jordan Gavaris

Siobhan 'Mrs. S' Sadler

Maria Doyle Kennedy

Detective Arthur 'Art' Bell

Kevin Hanchard

Delphine

Evelyne Brochu

Victor 'Vic' Schmidt

Michael Mando

Donald 'Donnie' Hendrix

Kristian Bruun

Mark/Rudy/Seth/Miller

Ari Millen

Scott Smith

Josh Vokey

Kira Manning

Skyler Wexler

Dr. Aldous Leekie

Matt Frewer

Shay Davydov

Ksenia Solo

Cal Morrison

Michiel Huisman

Kendall Malone

Alison Steadman

Jason Kellerman

Justin Chatwin

Willard Finch

Nicholas Campbell

Dr. Alan Nealon

Tom McCamus

Ferdinand Chevalier

James Frain

Connie Hendrix

Sheila McCarthy

Jonah Appleyard

David Fox

Bonnie Johanssen

Kristin Booth

Jesse

Patrick J. Adams

Young Rachel / Charlotte

Cynthia Galant

Gracie Johanssen

Zoé De Grand Maison

David Benchman

Tom Barnett

Sarah Stubbs

Terra Hazelton

Dr. Virginia Coady

Kyra Harper

Patty

Natalie Krill

Dr. Silva

Carlos Gonzalez-Vio

Ander

Andrew Martin Priestman

Vera

Trenna Keating

Gemma Hendrix

Millie Davis

Pouchy

Tony Cianchino

Bulldog

Earl Pastko

Marci Coates

Amanda Brugel

Alexis

Kathryn Alexandre

Professor Susan Duncan

Rosemary Dunsmore

Kassov

Nigel Bennett

Bobby

Diana Salvatore

Detective Angela "Angie" Deangelis

Inga Cadranel

La Camarera

Michelle Arvizu

Joao

David Vena

Hell Wizard

Calwyn Shurgold

Lieutenant Gavin Hardcastle

Ron Lea

Oscar Hendrix

Drew Davis

Detective Martin "Marty" Duko

Gord Rand

Evie Cho

Jessalyn Wanlim

Adele

Lauren Hammersley

Colin

Nicholas Rose

Aynsley Norris

Natalie Lisinska

Benjamin Kertland

Julian Richings

Reverend Mike / Reverend Mike (voice)

Ryan Blakely

Simon Frontenac

Andrew Moodie

Percival "P. T." Westmorland

Stephen McHattie

Daniel Rosen

Matthew Bennett

Ethan Duncan

Andrew Gillies

The Messenger

Géza Kovács

Detective Maddy Enger

Elyse Levesque

Sister Irina

Eileen Sword

Tomas

Daniel Kash

Olivier Duval

David Richmond-Peck

Henrik "Hank" Johanssen

Peter Outerbridge

Roxie

Miranda Edwards

Dr. Ian Van Lier

Scott Wentworth

Mud

Jenessa Grant

Aisha Yasin

Sirena Gulamgaus